Description

Tapentadol Hydrochloride

Tapentadol Hydrochloride is a high-purity, centrally acting analgesic used in pharmaceutical formulations for the management of moderate to severe acute or chronic pain. It combines μ-opioid receptor agonism with norepinephrine reuptake inhibition, providing dual-action pain relief with improved tolerability compared to traditional opioids. Tapentadol Hydrochloride
• Is a pharmaceutical-grade centrally acting analgesic for oral formulations
• Displays dual mechanism of action: μ-opioid receptor agonist and norepinephrine reuptake inhibitor
• Is used in immediate-release and extended-release tablet formulations
• Provides effective pain control for acute, chronic, and neuropathic pain
• Is manufactured under Good Manufacturing Practice (GMP) certified conditions
• Is supplied with complete regulatory documentation including Certificate of Analysis (CoA) and technical data
Tapentadol Hydrochloride is chemically designated as 3-[(1R,2R)-3-(Dimethylamino)-1-ethyl-2-methylpropyl]phenol hydrochloride. It appears as a white to off-white crystalline powder, freely soluble in water and ethanol, and stable under standard storage conditions.
In pharmaceutical applications, Tapentadol Hydrochloride is used in:
• Oral immediate-release tablets for acute pain management
• Extended-release formulations for chronic and neuropathic pain treatment
• Combination therapies targeting both nociceptive and neuropathic components of pain
• Clinical research and development of next-generation analgesic formulations
• Compounded preparations requiring consistent potency and solubility
Tapentadol Hydrochloride provides rapid onset and sustained pain control, reducing reliance on high-dose opioids and minimizing side effects such as nausea and constipation. Its dual mechanism of action allows for improved patient compliance and broader therapeutic applicability.
CarboMer supplies Tapentadol Hydrochloride with control over assay, polymorphic form, residual solvents, and microbial content. The material is suitable for regulated pharmaceutical manufacturing and oral dosage formulation.
The material is packaged in sealed, moisture-resistant, tamper-evident containers. Available in laboratory, pilot, and commercial-scale volumes. Minimum order quantities (MOQ), lead times, and documentation, including CoA and SDS, are provided upon request.
Each batch is tested for identity (IR, HPLC), assay (anhydrous basis), residual solvents, particle size, and microbial limits. Certificates of Analysis (CoA), Safety Data Sheets (SDS), and full traceability documentation accompany every shipment.
As with all CarboMer pharmaceutical-grade active ingredients, Tapentadol Hydrochloride is supported by formulation guidance, regulatory expertise, and a reliable global supply chain to ensure safe, effective, and compliant product performance.