Description

Sucrose Behenate

Sucrose Behenate is a high-purity, pharmaceutical-grade sucrose ester used in controlled-release oral dosage forms, lipid-based drug delivery systems, and coating applications. As a long-chain fatty acid ester of sucrose, it acts as a matrix-forming agent, film former, and hydrophobic excipient that supports sustained drug release and improved drug stability. Sucrose Behenate

• Is a lipophilic sucrose ester excipient used in oral controlled-release formulations
• Provides hydrophobic matrix structure in tablets, pellets, and multiparticulates
• Functions as a coating material for taste masking and moisture protection
• Is compatible with melt extrusion, spray congealing, and hot-melt granulation technologies

Sucrose Behenate is formed by the esterification of Sucrose with behenic acid (C22:0), a long-chain saturated fatty acid. The result is a waxy solid with high melting point and limited water solubility, making it ideal for use in matrix-controlled oral delivery systems. It is particularly useful for extended-release tablets and multiparticulate systems where a hydrophobic barrier is required.

In pharmaceutical formulations, Sucrose Behenate is used in:

• Sustained-release tablets and pellets as a hydrophobic matrix former
• Taste-masking and moisture-resistant coatings for bitter or hygroscopic actives
• Lipid-based solid dispersions to enhance the oral bioavailability of poorly soluble drugs
• Hot-melt extrusion and melt granulation processes for solvent-free production
• Multi-unit pellet systems (MUPS) and multiparticulate capsules requiring timed drug release

Sucrose Behenate provides mechanical strength and integrity to solid dosage forms while remaining physiologically inert and well tolerated. It is classified as a non-toxic, non-ionic surfactant with GRAS status for oral use.

CarboMer supplies Sucrose Behenate in optimized particle sizes and bulk density for uniform processing. The material is available as a free-flowing powder or granulate, suitable for direct compression, coating, or melt incorporation.

Each batch is tested for identity, melting point, acid value, saponification value, residual solvents, and microbial purity in accordance with internal specifications and compendial guidance where applicable. Packaging is provided in sealed, moisture-protected containers to maintain long-term stability.

As with all CarboMer excipients, Sucrose Behenate is fully supported by technical formulation expertise, regulatory documentation, and process development services to help clients advance lipid-based and controlled-release therapies to global markets.