Description

Rifapentine

Rifapentine is a high-purity, long-acting antibiotic used in pharmaceutical formulations for the treatment and prevention of mycobacterial infections, including tuberculosis. It functions by inhibiting bacterial DNA-dependent RNA polymerase, suppressing RNA synthesis, and preventing bacterial replication, making it an essential agent in combination anti-tuberculosis therapy. Rifapentine
• Is a pharmaceutical-grade antibiotic for oral administration
• Is effective against Mycobacterium tuberculosis and select gram-positive bacteria
• Is used in oral tablets and fixed-dose combination regimens for tuberculosis therapy
• Supports treatment and prophylaxis of latent and active tuberculosis
• Is manufactured under Good Manufacturing Practice (GMP) certified conditions
• Is supplied with complete regulatory documentation including Certificate of Analysis (CoA) and technical data
Rifapentine is chemically designated as 9-(4-Methylpiperazin-1-yl)rifamycin derivative. It appears as a reddish-orange crystalline powder with low solubility in water but suitable for oral formulation, providing sustained release and long half-life for extended dosing intervals.
In pharmaceutical applications, Rifapentine is used in:
• Oral tablets for combination therapy in active tuberculosis treatment
• Fixed-dose combinations with isoniazid, pyrazinamide, or other anti-TB drugs
• Prophylactic regimens for latent tuberculosis infection
• Clinical trials and research for anti-mycobacterial drug development
• Formulations requiring extended-release and long-acting pharmacokinetics
Rifapentine’s long half-life enables once-weekly or extended-interval dosing in combination therapies, improving patient compliance and treatment adherence. Its bactericidal activity contributes to effective suppression of Mycobacterium tuberculosis.
CarboMer supplies Rifapentine with control over assay, purity, residual solvents, and microbial content. The material is suitable for regulated pharmaceutical manufacturing and oral dosage formulation.
The material is packaged in sealed, moisture-resistant, tamper-evident containers. Available in laboratory, pilot, and commercial-scale quantities. Minimum order quantities (MOQ), lead times, and documentation including CoA and SDS are provided upon request.
Each batch is tested for identity (IR, HPLC), assay, water content, residual solvents, heavy metals, and microbial limits. Certificates of Analysis (CoA), Safety Data Sheets (SDS), and full traceability documentation accompany every shipment.
As with all CarboMer anti-mycobacterial APIs, Rifapentine is supported by formulation expertise, regulatory guidance, and a reliable global supply chain to ensure safe, effective, and compliant pharmaceutical products.