Description

Polysorbate 40

Polysorbate 40 is a high-purity, nonionic surfactant and emulsifier used extensively in pharmaceutical, biologic, and nutraceutical formulations to enhance the solubility, dispersion, and stability of poorly water-soluble ingredients. With its proven safety profile and multifunctional performance, it supports a broad range of drug delivery systems including parenteral, oral, ophthalmic, and topical products. Polysorbate 40

• Is a nonionic surfactant and solubilizer derived from sorbitol and palmitic acid
• Enhances aqueous solubility and dispersion of hydrophobic active pharmaceutical ingredients (APIs)
• Functions as an emulsifier, stabilizer, and wetting agent across diverse dosage forms
• Is fully compliant with USP/NF and Ph. Eur. pharmacopeial standards

Polysorbate 40 is composed of sorbitan palmitate esterified with approximately 20 moles of ethylene oxide, producing a hydrophilic-lipophilic balance (HLB) value suitable for stabilizing oil-in-water emulsions and dispersing lipophilic actives in aqueous environments. It is widely used to improve bioavailability, maintain product uniformity, and protect sensitive APIs from precipitation or aggregation.

In pharmaceutical applications, Polysorbate 40 is used as:

• A solubilizing agent in oral liquids, soft gels, and parenteral formulations for APIs with low water solubility
• An emulsifier and dispersant in topical creams, lotions, ophthalmic drops, and nasal sprays
• A stabilizer in protein and biologic formulations, reducing surface adsorption and aggregation
• A wetting agent in tablet coatings, suspensions, and transdermal delivery systems

Polysorbate 40 is also widely utilized in nutraceuticals and personal care products as a food-grade emulsifier, allowing crossover applications in oral and topical health solutions.

Pharmaceutical and nutraceutical formulators seeking to purchase Polysorbate 40 benefit from CarboMer’s consistent manufacturing quality, analytical controls, and full regulatory documentation to support global submissions.

The material is supplied in tamper-evident, light-resistant, moisture-protected packaging to maintain stability and product integrity during storage and shipment. Standard and bulk pack sizes are available, with minimum order quantities (MOQ) and lead times tailored to project needs.

Each batch is tested to meet pharmacopeial specifications (USP/NF, Ph. Eur.), including acid value, hydroxyl value, saponification value, peroxide content, heavy metals, and microbial limits. Full traceability and batch certification ensure confidence in compliance and reproducibility.

As with all CarboMer excipients, Polysorbate 40 is supported by our expert technical team, regulatory specialists, and formulation scientists, helping you bring innovative, stable, and compliant products to market efficiently.