Description

Pergolide USP

Pergolide USP is a high-purity dopamine receptor agonist used in pharmaceutical formulations for the treatment of Parkinson’s disease and hyperprolactinemia. As an ergoline-derived compound, Pergolide exhibits potent dopaminergic activity at D1 and D2 receptors, making it effective in improving motor control and reducing prolactin levels in endocrine disorders.

• USP-compliant dopaminergic agent for neurology and endocrine use
• Used in oral dosage forms for Parkinson’s disease and prolactin-secreting adenomas
• Activates D1 and D2 receptors to support dopaminergic neurotransmission
• Exhibits long plasma half-life and strong receptor affinity
• Manufactured under Good Manufacturing Practice (GMP) certified conditions
• Supplied with full regulatory documentation including Certificate of Analysis (CoA), Drug Master File (DMF), and supporting technical data

Chemically known as 8β-[Methylthio]-6-propylergoline, Pergolide is typically formulated as the mesylate or hydrochloride salt. It appears as a white to off-white powder and is commonly used in extended-release oral tablets.

In pharmaceutical applications, Pergolide USP is used in:

• Monotherapy or adjunct therapy in Parkinson’s disease, particularly in early to mid-stage treatment
• Management of hyperprolactinemia and prolactinomas where dopamine agonists are indicated
• Veterinary formulations (e.g., equine Cushing’s disease) under regulatory authorization
• Clinical research into dopamine-modulated neuropsychiatric disorders

Pergolide helps restore dopaminergic tone in the basal ganglia, reducing tremors, rigidity, and bradykinesia. It also inhibits prolactin release from the anterior pituitary, addressing hormonal imbalances in reproductive and endocrine conditions.

Due to the potential for valvular heart effects with long-term use, formulations must comply with strict dosing and pharmacovigilance guidelines. CarboMer supplies Pergolide USP with rigorous controls on assay, optical purity, heavy metals, and degradation products.

Material is packaged in sealed, light-resistant, tamper-evident containers and should be stored under refrigeration to preserve potency. Available in R&D and commercial volumes. Minimum order quantities (MOQ), lead times, and documentation including CoA, SDS, and DMF access are provided upon request.

Each batch is tested for identity (IR, HPLC), assay (anhydrous basis), optical rotation, water content, related substances, heavy metals, and microbial limits. All shipments are accompanied by Certificates of Analysis (CoA), Safety Data Sheets (SDS), and traceability documentation.

As with all CarboMer neurology APIs, Pergolide USP is supported by formulation development expertise, regulatory strategy, and a secure global supply chain to ensure successful delivery of CNS and endocrine therapies.