Description

Lactulose

Lactulose is a high-purity synthetic disaccharide used as an active pharmaceutical ingredient (API) in the treatment of constipation and hepatic encephalopathy. It functions as an osmotic laxative in the colon and promotes the growth of beneficial gut flora while reducing ammonia absorption in patients with liver dysfunction. Lactulose

• Is a pharmaceutical-grade synthetic disaccharide composed of galactose and fructose
• Is used in oral solutions and syrups for chronic constipation and hepatic encephalopathy
• Exhibits osmotic laxative activity and promotes acidification of colonic contents
• Supports ammonia detoxification and nitrogen elimination in liver disease
• Is manufactured under Good Manufacturing Practice (GMP) conditions
• Is supplied with complete regulatory documentation including Certificate of Analysis (CoA) and supporting technical data

Lactulose is a clear to pale-yellow viscous liquid with a sweet taste. It is not absorbed in the small intestine and is fermented by colonic bacteria, resulting in increased osmotic pressure, stool water content, and peristalsis. Additionally, fermentation lowers colonic pH, facilitating conversion of ammonia (NH₃) to ammonium (NH₄⁺), which cannot be reabsorbed.

In pharmaceutical applications, Lactulose is used in:

• Oral liquid preparations (usually 10 g/15 mL) for treating chronic or opioid-induced constipation
• Prescription medications for hepatic encephalopathy to reduce systemic ammonia levels
• Gastrointestinal health supplements and prebiotic formulations in certain markets
• Neonatal and pediatric GI therapies, where gentle laxative action is needed
• Adjunct therapy for gut flora regulation and microbiota balance

Lactulose begins to act within 24–48 hours and is considered safe for long-term use under medical supervision. It may cause mild bloating or gas due to fermentation, especially during early use.

CarboMer supplies Lactulose in syrup-grade and concentrate-grade formats, compliant with pharmacopeial standards (USP, EP). Each batch is manufactured under GMP conditions with tight controls on galactose, lactose, fructose, and heavy metal content.

The material is packaged in sealed, light-protected, tamper-evident containers suitable for viscous liquids. Available in clinical, pilot, and commercial-scale quantities. Minimum order quantities (MOQ), lead times, and documentation—including CoA and SDS—are available upon request.

Each batch is tested for identity (HPLC, IR), assay (lactulose content), related sugars (galactose, lactose, epilactose), pH, color, and microbial limits. Certificates of Analysis (CoA), Safety Data Sheets (SDS), and traceability documentation accompany every shipment.

As with all CarboMer APIs and excipients for gastrointestinal health, Lactulose is supported by regulatory expertise, formulation assistance, and reliable supply to help you deliver safe, effective therapies for constipation management and hepatic care.