Dextran Sulfate

Description

Dextran Sulfate is a high-purity, sulfated polysaccharide used in pharmaceutical, biochemical, and biomedical applications for its anticoagulant, antiviral, and macromolecule-binding properties. Derived from controlled sulfation of Dextran, it exhibits strong polyanionic characteristics and is widely used in research, drug development, and specialized clinical formulations.

Dextran Sulfate is chemically designated as the sulfuric acid ester of Dextran, typically produced from glucose polymers linked by α-(1→6) bonds with varying degrees of branching. It appears as a white to off-white hygroscopic powder that is freely soluble in water, producing clear or slightly opalescent solutions.

In pharmaceutical, biomedical, and research applications, Dextran Sulfate is used in:

• Anticoagulant and antithrombotic formulations

• Viral inhibition and research on viral entry mechanisms

• Plasma volume expanders and osmotic agents (in specific molecular weight grades)

• Chromatography resins and purification systems due to its polyanionic nature

• Cell culture, molecular biology, and receptor-binding studies

• Controlled-release and drug delivery systems involving charged polymer matrices

Dextran Sulfate functions by interacting with proteins, enzymes, and cell surfaces through its high negative charge density. It can inhibit coagulation pathways, bind growth factors, and interfere with viral attachment processes. Its unique chemical structure allows for versatile use across both therapeutic and analytical platforms.

CarboMer supplies Dextran Sulfate with validated control over sulfur content, molecular weight distribution, purity, viscosity, and microbial quality. Material is manufactured under strict quality systems and tailored for regulated pharmaceutical and laboratory applications.

Material is packaged in sealed, moisture-resistant, tamper-evident containers. Available in laboratory, pilot, and commercial-scale quantities. Documentation includes Certificate of Analysis (CoA), Safety Data Sheet (SDS), and full traceability.

Each batch is tested for identity (IR), sulfur content, molecular weight profile, pH, loss on drying, and microbial limits. CarboMer provides technical and regulatory support to ensure consistent performance in both research and production environments.

As with all CarboMer polysaccharide-based ingredients, Dextran Sulfate is supported by reliable global supply, stringent quality control, and expert formulation guidance to ensure safe, effective, and reproducible application performance.