Description

Alprostadil USP

Alprostadil USP is a high-purity prostaglandin E1 (PGE1) analog used in pharmaceutical formulations for vasodilation, platelet inhibition, and smooth muscle relaxation. Compliant with United States Pharmacopeia (USP) standards, it is employed in the treatment of erectile dysfunction, pulmonary hypertension, and neonatal ductus arteriosus maintenance prior to corrective cardiac surgery. Alprostadil USP
• Is a USP-compliant prostaglandin E1 analog for pharmaceutical use
• Is used in injectable, topical, and transurethral formulations
• Promotes vasodilation, platelet inhibition, and tissue perfusion
• Is suitable for cardiovascular, urological, and neonatal therapeutic applications
• Is manufactured under Good Manufacturing Practice (GMP) certified conditions
• Is supplied with complete regulatory documentation including Certificate of Analysis (CoA) and technical data
Alprostadil is chemically designated as (5Z,11α,13E,15S)-11,15-Dihydroxy-9-oxoprost-13-en-1-oic acid. It appears as a white to off-white crystalline powder that is practically insoluble in water but soluble in ethanol and organic solvents. Due to its sensitivity to light and oxygen, it is typically formulated under inert and light-protective conditions.
In pharmaceutical applications, Alprostadil USP is used in:
• Injectable formulations for erectile dysfunction and peripheral vascular disease
• Neonatal infusions to maintain ductus arteriosus patency in congenital heart defects
• Topical and transurethral preparations for localized vasodilatory therapy
• Clinical research and development of prostaglandin-based cardiovascular agents
• Compounded preparations for specialized therapeutic formulations
Alprostadil USP acts by activating Adenylate cyclase, increasing cyclic adenosine monophosphate (cAMP) levels, and inducing smooth muscle relaxation in vascular and cavernosal tissues. It also inhibits platelet aggregation and improves microcirculation in ischemic tissues.
CarboMer supplies Alprostadil USP that is characterized by assay, isomeric purity, residual solvents, and stability. The material meets USP monograph specifications and is suitable for regulated pharmaceutical manufacturing and clinical use.
The material is packaged in sealed, light-resistant, tamper-evident containers. It is available in laboratory, pilot, and commercial-scale quantities. Minimum order quantities (MOQ), lead times, and documentation including CoA and SDS are provided upon request.
Each batch is tested for identity (IR, HPLC), assay (anhydrous basis), isomeric purity, water content, and stability. Certificates of Analysis (CoA), Safety Data Sheets (SDS), and full traceability documentation accompany every shipment.
As with all CarboMer prostaglandin and cardiovascular APIs, Alprostadil USP is supported by formulation guidance, regulatory expertise, and dependable global supply to ensure safe, effective, and compliant pharmaceutical product performance.