Description

Alprostadil alfadex

Alprostadil Alfadex is a pharmaceutical-grade inclusion complex of alprostadil (Prostaglandin E1) with α-Cyclodextrin, designed to improve the solubility, stability, and bioavailability of alprostadil in injectable and topical formulations. This complex is used primarily in the treatment of erectile dysfunction and peripheral vascular disorders. Alprostadil Alfadex

• Is a high-purity inclusion complex of Alprostadil and α-cyclodextrin
• Enhances aqueous solubility and chemical stability of Alprostadil
• Suitable for injectable and urethral formulations for erectile dysfunction
• Enables precise dosing and improved handling characteristics
• Manufactured under Good Manufacturing Practice (GMP) conditions
• Supplied with complete regulatory documentation including Certificate of Analysis (CoA) and supporting technical data

Alprostadil is a naturally occurring Prostaglandin E1 that induces vasodilation and smooth muscle relaxation by increasing intracellular cyclic AMP. While highly effective, its formulation is challenging due to poor water solubility and susceptibility to hydrolysis and oxidation. Complexation with α-Cyclodextrin significantly increases solubility, improves chemical stability, and simplifies processing.

In pharmaceutical applications, Alprostadil Alfadex is used in:

• Injectable formulations for intracavernosal administration in erectile dysfunction
• Urethral suppositories and gels for local delivery with improved tolerability
• Investigational delivery systems, including transdermal and biodegradable implants
• Peripheral vascular disease treatments, where controlled vasodilation is beneficial

The inclusion complex preserves the pharmacological activity of alprostadil while improving its handling characteristics and enabling more precise dosing in sterile dosage forms.

CarboMer supplies Alprostadil Alfadex with rigorous controls over inclusion efficiency, residual solvents, microbial content, and endotoxins to meet the stringent requirements of parenteral formulations. Each batch is traceable and produced under GMP conditions to support regulatory submissions worldwide.

The material is packaged in sealed, light-protected, tamper-evident containers to maintain potency and prevent degradation. Available in R&D, pilot, and commercial quantities. Minimum order quantities (MOQ), lead times, and technical documentation are available upon request.

Each batch is tested for identity, alprostadil content, degree of inclusion, residual solvents, endotoxins, and microbial purity. Certificates of Analysis (CoA), Safety Data Sheets (SDS), and full analytical data accompany every shipment.

As with all CarboMer APIs and complex excipients, Alprostadil Alfadex is supported by technical formulation guidance, regulatory expertise, and dependable supply chain management to help you bring high-quality urologic and vascular therapies to market.