Description

Valproic Acid USP/EP

Valproic Acid USP/EP is a high-purity, pharmaceutical-grade antiepileptic and mood stabilizing agent used in oral and parenteral formulations for the treatment of epilepsy, bipolar disorder, and migraine prophylaxis. As a broad-spectrum anticonvulsant, Valproic Acid is effective in managing generalized and partial seizures through multiple mechanisms of action. Valproic Acid

• Is compliant with both United States Pharmacopeia (USP) and European Pharmacopoeia (EP) monographs
• Enhances GABAergic neurotransmission and modulates Sodium and Calcium channel activity
• Is indicated for epilepsy, bipolar disorder, and migraine prevention
• Is suitable for oral solutions, syrups, softgel capsules, and intravenous formulations
• Is manufactured under Good Manufacturing Practice (GMP) conditions
• Is supplied with full regulatory documentation including Certificate of Analysis (CoA) and supporting technical data

Valproic Acid (2-Propylpentanoic Acid) exerts its antiepileptic effects by increasing Gamma-Aminobutyric Acid (GABA) concentrations in the brain, reducing neuronal excitability, and stabilizing electrical activity. Its multimodal mechanism also includes inhibition of voltage-gated Sodium channels and T-type Calcium channels, providing efficacy across seizure types.

In pharmaceutical formulations, Valproic Acid USP/EP is used in:

• Oral liquid formulations (e.g., syrups, solutions) for pediatric and geriatric administration
• Soft gelatin capsules and extended-release tablets for once- or twice-daily dosing
• Intravenous solutions for acute management of seizures when oral administration is not possible
• Fixed-dose combinations in bipolar disorder management and migraine prophylaxis

CarboMer supplies Valproic Acid USP/EP with tight control of residual solvents, related impurities, and microbial content. The API meets stringent pharmacopeial standards to ensure safety, efficacy, and reproducibility in all dosage forms.

The material is packaged in sealed, tamper-evident, moisture-resistant containers. Available in standard and bulk quantities to support R&D through commercial manufacturing. Minimum order quantities (MOQ), lead times, and regulatory documentation including FDA Type II DMF access are available upon request.

Each batch is fully tested for identity, assay, related substances, residual solvents, and microbial limits according to USP and EP specifications. Certificates of Analysis (CoA), Safety Data Sheets (SDS), and full traceability documentation are included.

As with all CarboMer APIs, Valproic Acid USP/EP is supported by expert formulation consulting, regulatory assistance, and reliable supply chain management helping you develop safe, effective CNS therapies with confidence.