Description

Trimethoprim USP

Trimethoprim USP is a high-purity antibacterial agent used in pharmaceutical formulations for the treatment and prevention of a variety of bacterial infections. Compliant with United States Pharmacopeia (USP) standards, it is commonly used alone or in combination with sulfonamides for enhanced antibacterial efficacy.
Trimethoprim is chemically designated as 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine. It appears as a white to off-white crystalline powder that is slightly soluble in water and freely soluble in alcohol, supporting formulation into oral solid dosage forms.
In pharmaceutical and clinical applications, Trimethoprim USP is used in:
• Oral tablets and capsules for treatment of bacterial infections
• Combination antibiotic products, including with Sulfamethoxazole
• Management of urinary tract and respiratory tract infections
• Prophylaxis in immunocompromised patients
• Research involving bacterial folate metabolism inhibition
• Pharmacological and microbiological studies
Trimethoprim USP functions by selectively inhibiting bacterial Dihydrofolate reductase, an enzyme essential for folic acid synthesis. This inhibition prevents bacterial DNA synthesis and cell replication while exhibiting selective toxicity toward bacterial cells over mammalian cells.
CarboMer supplies Trimethoprim USP with details of assay, purity, residual solvents, particle size, and microbial quality. The material meets USP monograph specifications and is suitable for regulated pharmaceutical manufacturing.
The material is packaged in sealed, moisture-resistant, tamper-evident containers. Available in laboratory, pilot, and commercial-scale quantities. Documentation includes Certificate of Analysis (CoA), Safety Data Sheet (SDS), and complete traceability.
Each batch is tested for identity (IR, HPLC), assay on anhydrous basis, impurity profile, water content, and microbial limits. Technical support is available to assist with formulation development and regulatory compliance.
As with all CarboMer supplied antibacterial active ingredients, Trimethoprim USP is supported by dependable global supply, stringent quality control, and expert technical guidance to ensure safe, effective, and consistent pharmaceutical product development.