Description

Trimetazidine Hydrochloride

Trimetazidine Hydrochloride is a high-purity metabolic antianginal agent used in pharmaceutical formulations for the management of ischemic heart disease and related cardiovascular conditions. It improves myocardial energy metabolism without affecting heart rate or blood pressure, making it suitable as an adjunct therapy in patients with stable angina.
Trimetazidine Hydrochloride is chemically designated as 1-(2,3,4-Trimethoxybenzyl)piperazine Dihydrochloride. It appears as a white to off-white crystalline powder that is freely soluble in water and soluble in alcohol, allowing formulation into oral solid and liquid dosage forms.
In pharmaceutical and clinical applications, Trimetazidine Hydrochloride is used in:
• Oral tablets for treatment of stable angina pectoris
• Adjunct therapy in ischemic heart disease
• Management of metabolic dysfunction associated with myocardial ischemia
• Research involving cellular energy metabolism and cardio protection
• Pharmacokinetic and bioavailability studies
Trimetazidine Hydrochloride functions by inhibiting mitochondrial long-chain 3-Ketoacyl CoA Thiolase, shifting myocardial energy metabolism from fatty acid oxidation toward more efficient glucose oxidation. This metabolic modulation improves cellular tolerance to ischemia and preserves myocardial function under hypoxic conditions.
CarboMer supplies Trimetazidine Hydrochloride with details of assay, purity, residual solvents, particle size, and microbial quality. The material is suitable for regulated pharmaceutical development and commercial manufacturing.
The material is packaged in sealed, moisture-resistant, tamper-evident containers and protected from excessive light. Available in laboratory, pilot, and commercial-scale quantities. Documentation includes Certificate of Analysis (CoA), Safety Data Sheet (SDS), and complete traceability.
Each batch is tested for identity (IR, HPLC), assay on anhydrous basis, impurity profile, water content, and microbial limits. Technical support is available to assist with formulation development and regulatory compliance.
As with all CarboMer supplied cardiovascular active ingredients, Trimetazidine Hydrochloride is supported by dependable global supply, stringent quality control, and expert technical guidance to ensure safe, effective, and consistent pharmaceutical product development.