Description

Tolnaftate USP

Tolnaftate USP is a high-purity, pharmaceutical-grade synthetic thiocarbamate antifungal used in topical formulations for the treatment of dermatophytic infections such as athlete’s foot (tinea pedis), jock itch (tinea cruris), and ringworm (tinea corporis). It acts by inhibiting the biosynthesis of ergosterol, a key component of fungal cell membranes. Tolnaftate is

• A USP-compliant antifungal active pharmaceutical ingredient (API)
• Effective against dermatophytes including Trichophyton, Microsporum, and Epidermophyton species
• Suitable for topical dosage forms such as creams, powders, sprays, and gels
• Chemically stable, non-irritating, and well tolerated for long-term application
• Manufactured under Good Manufacturing Practice (GMP) conditions
• Supplied with full regulatory documentation including Certificate of Analysis (CoA) and supporting technical data

Tolnaftate is chemically described as O-2-Naphthyl methyl(3-ethylphenyl)thiocarbamate. It is practically insoluble in water, requiring incorporation into appropriate topical vehicles for effective delivery to infected keratinized tissues. Tolnaftate’s mechanism of action disrupts fungal cell membrane integrity, leading to inhibition of growth and proliferation.

In pharmaceutical applications, Tolnaftate USP is used in:

• Topical creams, ointments, and gels for treatment and prevention of dermatophytoses
• Powders and aerosols for application to feet, groin, and other susceptible areas
• Combination products with keratolytic or drying agents to enhance efficacy and patient comfort
• OTC antifungal therapies approved in multiple jurisdictions

CarboMer supplies Tolnaftate USP with tight control over polymorphic form, particle size, and residual solvent levels to ensure uniform dispersion and reliable performance across dosage forms. The product meets or exceeds all USP monograph specifications for identity, assay, impurities, and microbial limits.

The API is packaged in sealed, tamper-evident containers to protect against moisture and contamination. Available in R&D, pilot, and commercial-scale quantities. Minimum order quantities (MOQ), lead times, and regulatory support are provided to facilitate product development and global registration.

Each batch is fully tested for compliance with USP specifications, including appearance, identification, assay, loss on drying, and related substances. Certificates of Analysis (CoA), Safety Data Sheets (SDS), and full traceability documentation are included.

As with all CarboMer APIs, Tolnaftate USP is supported by expert formulation guidance, regulatory consultation, and supply chain continuity to help you advance high-quality antifungal therapies to market.