Description

Tobramycin USP

Tobramycin USP is a high-purity, aminoglycoside antibiotic used in pharmaceutical formulations for the treatment of severe bacterial infections caused by gram-negative organisms. Compliant with United States Pharmacopeia (USP) standards, it is commonly formulated in injectable, ophthalmic, and topical dosage forms due to its potent bactericidal activity and well-defined pharmacokinetics. Tobramycin USP is
• A USP-compliant aminoglycoside antibiotic for pharmaceutical use
• Effective against gram-negative bacteria, including Pseudomonas aeruginosa
• Used in injectable, ophthalmic, and topical formulations
• Suitable for systemic, ocular, and localized infection management
• Manufactured under Good Manufacturing Practice (GMP) certified conditions
• Supplied with complete regulatory documentation including Certificate of Analysis (CoA) and technical data
Tobramycin USP is chemically designated as O-3-Amino-3-deoxy-α-D-glucopyranosyl-(1→6)-O-[2,6-diamino-2,3,6-trideoxy-α-D-ribo-hexopyranosyl-(1→4)]-2-deoxy-D-streptamine. It appears as a white to off-white amorphous powder, freely soluble in water, and stable under controlled storage conditions.
In pharmaceutical applications, Tobramycin USP is used in:
• Injectable formulations for systemic bacterial infections, including septicemia and respiratory infections
• Ophthalmic drops and ointments for bacterial conjunctivitis and keratitis
• Topical formulations for skin and wound infections
• Combination therapies with beta-lactam antibiotics for synergistic antibacterial action
• Veterinary and research formulations requiring aminoglycoside activity
Tobramycin USP acts by binding irreversibly to the 30S subunit of bacterial ribosomes, inhibiting protein synthesis and causing cell death. Its potent, concentration-dependent bactericidal action makes it a key therapeutic option for resistant gram-negative infections.
CarboMer supplies Tobramycin USP with control over potency, assay, water content, residual solvents, and microbial purity. Each batch meets USP monograph specifications and is suitable for regulated pharmaceutical manufacturing.
The material is packaged in sealed, moisture-protective, tamper-evident containers. It is available in laboratory, pilot, and commercial-scale volumes. Minimum order quantities (MOQ), lead times, and documentation—including CoA and SDS—are provided upon request.
Each batch is tested for identity (HPLC, microbiological assay), potency, water content, pH, and microbial limits. Certificates of Analysis (CoA), Safety Data Sheets (SDS), and full traceability documentation accompany every shipment.
As with all CarboMer antibiotic APIs, Tobramycin USP is supported by formulation guidance, regulatory expertise, and dependable global supply to ensure safe, effective, and compliant pharmaceutical products.