Description

Sulfopropyl-β-Cyclodextrin

Sulfopropyl-β-Cyclodextrin (SP-β-CD) is a high-performance anionic cyclodextrin derivative used in pharmaceutical formulations as a solubilizer, complexing agent, and excipient for poorly soluble active pharmaceutical ingredients (APIs). Its sulfonic acid functionalization enhances aqueous solubility, ionic interaction, and inclusion complex stability—making it ideal for parenteral, ophthalmic, and oral delivery systems.

• Modified β-cyclodextrin with sulfonic acid side chains for enhanced ionic solubilization

• Improves water solubility and bioavailability of hydrophobic drugs

• Used in injectables, ophthalmic solutions, oral liquids, and solid dosage forms

• Low toxicity and non-immunogenic profile; suitable for parenteral use

• Manufactured under Good Manufacturing Practice (GMP) certified conditions

• Supplied with complete regulatory documentation including Certificate of Analysis (CoA) and supporting technical data

Sulfopropyl-β-Cyclodextrin consists of a seven-glucose ring modified with sulfopropyl groups on the hydroxyl sites, conferring a net negative charge and improved solubility in aqueous media. It forms stable inclusion complexes with lipophilic drug molecules via non-covalent interactions, significantly improving dissolution and stability profiles.

In pharmaceutical applications, Sulfopropyl-β-Cyclodextrin is used in:

• Parenteral formulations to enable IV delivery of water-insoluble APIs

• Ophthalmic products where drug solubility and ocular tolerability are critical

• Oral liquids and suspensions for pediatric and geriatric administration

• Nasal and pulmonary delivery systems to enhance local absorption and minimize excipient toxicity

• Stabilization of sensitive actives against hydrolysis, oxidation, or photodegradation

Compared to natural cyclodextrins, SP-β-CD offers higher complexation efficiency, improved drug loading, and ionic stabilization in aqueous systems—without inducing hemolysis or nephrotoxicity at therapeutic levels.

CarboMer supplies Sulfopropyl-β-Cyclodextrin with validated control over degree of substitution (DS), molecular weight distribution, residual solvents, and endotoxin content. Material is suitable for regulated use in parenteral, ophthalmic, and oral pharmaceutical formulations.

Material is packaged in sealed, tamper-evident, moisture- and light-protective containers. Available in research, clinical, and commercial quantities. Minimum order quantities (MOQ), lead times, and documentation—including CoA, SDS, and regulatory support—are provided upon request.

Each batch is tested for identity (NMR, HPLC), degree of substitution, moisture content, residual solvents, microbial limits, and endotoxin levels. Certificates of Analysis (CoA), Safety Data Sheets (SDS), and full traceability documentation accompany every shipment.

As with all CarboMer functional excipients and drug delivery agents, Sulfopropyl-β-Cyclodextrin is supported by formulation expertise, regulatory guidance, and global sourcing to accelerate the development of advanced and bioavailable pharmaceutical products.