Description

Sucrose Polybehenate

Sucrose Polybehenate is a lipophilic, high-molecular-weight sucrose ester used in controlled-release pharmaceutical formulations. As a multi-ester of sucrose and behenic acid (C22:0), it functions as a hydrophobic matrix-forming agent, sustained-release excipient, and lipid coating The material in oral solid dosage forms designed for extended or delayed drug release. Sucrose Polybehenate

• Is a hydrophobic sucrose ester composed of multiple behenic acid moieties
• Is used in sustained-release tablets, pellets, granules, and multiparticulate systems
• Supports hot-melt granulation, melt extrusion, and spray congealing processes
• Provides uniform, pH-independent release profiles for poorly soluble APIs

Sucrose Polybehenate is structurally similar to monoesters like Sucrose Behenate but contains a higher degree of esterification, which enhances its melting point, hydrophobicity, and film-forming characteristics. It is ideal for extended-release formulations where controlled matrix erosion or diffusion is required, especially in multi-unit pellet systems (MUPS) or high drug-load tablets.

In pharmaceutical development, Sucrose Polybehenate is used in:

• Controlled-release oral solid dosage forms to modulate drug release over 12–24 hours
• Hot-melt granulation and extrusion systems as a matrix former or release modifier
• Multiparticulate formulations including capsules filled with coated granules or beads
• Taste-masking and barrier coatings to protect APIs from moisture or premature release
• Lipid-based formulations where a waxy, long-chain fatty ester improves matrix uniformity

The excipient’s lipophilic profile provides minimal interaction with gastric fluids and ensures pH-independent drug release. It can be combined with hydrophilic excipients to fine-tune drug release kinetics and improve bioavailability of poorly soluble actives.

CarboMer supplies Sucrose Polybehenate in fine powder or pellet form with optimized flow and melting properties for process integration. Each lot is produced under validated, GMP-controlled conditions and accompanied by detailed analytical and quality data.

The product is packaged in sealed, moisture-resistant containers for optimal long-term stability. Multiple pack sizes are available to support early development through commercial-scale manufacturing. Minimum order quantities (MOQ), lead times, and regulatory documentation are available upon request.

Each batch is tested for ester value, acid value, melting point, residual solvents, and microbial purity, and meets strict internal specifications aligned with international regulatory expectations.

As with all CarboMer excipients, Sucrose Polybehenate is supported by expert technical formulation services, regulatory consulting, and reliable global supply to help partners bring innovative extended-release oral products to market with confidence.