Description

Sildenafil Citrate

Sildenafil Citrate is a high-purity, pharmaceutical-grade phosphodiesterase type 5 (PDE5) inhibitor used in oral formulations for the treatment of erectile dysfunction (ED) and pulmonary arterial hypertension (PAH). As a selective and potent vasodilator, it enhances nitric oxide–mediated smooth muscle relaxation and improves vascular blood flow in targeted tissues. Sildenafil Citrate is

• A pharmaceutical-grade PDE5 inhibitor with well-characterized safety and efficacy
• Indicated for erectile dysfunction and pulmonary arterial hypertension
• Suitable for solid oral dosage forms: tablets, capsules, orally disintegrating tablets (ODTs)
• A water-soluble citrate salt that ensures consistent bioavailability and rapid absorption

Chemically known as 1-[[3-(6,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]sulfonyl]-4-methylpiperazine citrate, Sildenafil acts by inhibiting PDE5, the enzyme responsible for degrading cyclic Guanosine monophosphate (cGMP). Inhibition of PDE5 results in increased cGMP levels, prolonged smooth muscle relaxation, and enhanced blood flow particularly in the corpus cavernosum of the penis and pulmonary vasculature.

In pharmaceutical formulations, Sildenafil Citrate is used in:

• Erectile dysfunction therapies, such as monotherapy or in combination with other agents
• Pulmonary arterial hypertension treatments, often under modified-release or titrated regimens
• Oral disintegrating tablets (ODTs) and film-coated tablets for rapid onset and patient compliance
• Investigational uses, including female sexual arousal disorders and vascular-related off-label conditions

CarboMer supplies Sildenafil Citrate with controlled polymorphic form, tight particle size distribution, and defined impurity profile to ensure consistency and compliance in global markets. The product conforms to pharmacopeial standards (e.g., USP, EP) and is suitable for commercial-scale manufacturing.

The material is provided in sealed, light-resistant, tamper-evident packaging, with multiple pack sizes available for both clinical development and full-scale production. Minimum order quantities (MOQ), lead times, and full regulatory support are available upon request.

Each batch is tested for identity, assay, polymorphic consistency, residual solvents, heavy metals, and microbiological purity. Certificates of Analysis (CoA) and Safety Data Sheets (SDS) are provided.

As with all CarboMer APIs, Sildenafil Citrate is backed by expert technical guidance, regulatory support, and lifecycle documentation to streamline your product development from lab to launch.