Description

R-(+)-Propanolol HCl

R-(+)-Propranolol HCl is the pharmacologically active enantiomer of Propranolol hydrochloride, a non-selective beta-adrenergic receptor blocker used in the treatment of hypertension, cardiac arrhythmias, angina pectoris, and anxiety-related conditions. This single-enantiomer form provides stereospecific β-blocking activity with the potential for improved safety and efficacy over the racemic mixture. R-(+)-Propranolol HCl

• Is an enantiomerically pure, high-purity non-selective β-adrenergic blocker
• In the R-(+) form is responsible for the clinical β1 and β2 antagonistic effects
• Is suitable for oral and parenteral pharmaceutical formulations
• As water-soluble Hydrochloride salt ensures formulation versatility and consistent absorption

Propranolol is commonly administered as a racemic mixture (R,S-Propranolol), although only the R-(+) enantiomer exhibits significant β-adrenergic receptor blocking activity. By isolating the R-(+) form, developers can eliminate unnecessary exposure to the inactive S-(−) enantiomer, potentially reducing metabolic burden or non-specific interactions.

In pharmaceutical applications, R-(+)-Propranolol HCl is used for:

• Management of hypertension through non-selective β1/β2 antagonism
• Chronic treatment of angina pectoris and arrhythmias to reduce cardiac workload and control heart rate
• Adjunctive treatment for performance anxiety or essential tremor where rapid central nervous system penetration is required
• Development of stereochemically optimized formulations, such as modified-release or fixed-dose combinations where precision is critical

R-(+)-Propranolol HCl is specially valuable in chiral switch programs, enabling lower total API dosages and cleaner pharmacokinetic profiles, and may support future regulatory filings focused on enantiomer-specific drug approvals.

CarboMer supplies R-(+)-Propranolol HCl with high chiral purity (≥99% ee) and rigorous quality control to ensure batch consistency, including optical rotation, assay, and enantiomeric excess (EE) via chiral HPLC or Capillary electrophoresis methods.

The material is packaged in sealed, moisture- and light-protected containers and is available in both R&D and commercial-scale pack sizes. Minimum order quantities (MOQ), lead times, and full documentation including CoA, SDS are provided with each lot.

Each batch undergoes comprehensive analytical testing for chiral and chemical purity, residual solvents, heavy metals, microbial limits, and compliance with USP standards as applicable.

As with all CarboMer APIs, R-(+)-Propranolol HCl is fully supported by technical formulation guidance, regulatory consulting, and documentation services to accelerate development of high-precision cardiovascular therapeutics for global markets.