Description

Quinine Sulfate Dihydrate USP

Quinine Sulfate Dihydrate USP is a high-purity, pharmaceutical-grade alkaloid used for its antimalarial and antipyretic properties. Compliant with United States Pharmacopeia (USP) standards, it is widely utilized in oral dosage forms and parenteral solutions for the treatment of malaria, as well as in certain off-label applications for leg cramps and cardiac arrhythmias. Quinine Sulfate Dihydrate
• Is a USP-compliant antimalarial alkaloid with therapeutic efficacy
• Is used in oral tablets, capsules, and parenteral formulations
• Provides rapid absorption and reliable pharmacokinetic profile
• Is suitable for treatment of malaria, nocturnal leg cramps, and selected cardiac arrhythmias
• Is manufactured under Good Manufacturing Practice (GMP) certified conditions
• Is supplied with complete regulatory documentation including Certificate of Analysis (CoA) and technical data
Quinine Sulfate Dihydrate is chemically designated as (R)-[(2S,4S,5R,6R)-6-(Hydroxyethyl)-1-azabicyclo[2.2.2]octan-2-yl]quinoline sulfate dihydrate. It appears as a white to off-white crystalline powder with high solubility in water and alcohols, enabling consistent dosing and formulation flexibility.
In pharmaceutical applications, Quinine Sulfate Dihydrate USP is used in:
• Oral tablets and capsules for prophylactic and therapeutic malaria treatment
• Parenteral formulations for severe malaria cases and intravenous therapy
• Topical and compounded formulations for research or specialized applications
• Clinical studies targeting nocturnal leg cramps or specific arrhythmic conditions
• Combination therapies with other antimalarial agents for enhanced efficacy
Quinine Sulfate Dihydrate works by inhibiting the parasite’s ability to digest hemoglobin, disrupting its life cycle and reducing parasitemia. Its predictable absorption and distribution make it suitable for both acute treatment and prophylaxis.
CarboMer supplies Quinine Sulfate Dihydrate USP with control over assay, water content, residual solvents, and microbial purity. Each batch meets USP monograph specifications and is suitable for regulated pharmaceutical use.
The material is packaged in sealed, moisture-resistant, tamper-evident containers. Available in laboratory, pilot, and commercial-scale volumes. Minimum order quantities (MOQ), lead times, and documentation including CoA and SDS are provided upon request.
Each batch is tested for identity (IR, HPLC), assay, water content, sulfate content, heavy metals, and microbial limits. Certificates of Analysis (CoA), Safety Data Sheets (SDS), and full traceability documentation accompany every shipment.
As with all CarboMer pharmaceutical alkaloid APIs, Quinine Sulfate Dihydrate USP is supported by formulation guidance, regulatory expertise, and a reliable global supply chain to ensure safe, effective, and compliant pharmaceutical products.