Description

Pustulan

Pustulan is a high-purity, pharmaceutical-grade β-(1→6)-glucan used in advanced drug delivery systems and biomedical formulations for its biocompatibility, immunomodulatory potential, and bioadhesive properties. Derived from lichen species, Pustulan exhibits water solubility, film-forming capability, and structural similarity to biologically active glucans, making it suitable for mucosal delivery, wound healing systems, and immune-supportive applications. Pustulan

• Is a β-(1→6)-linked glucose polymer with defined high molecular weight
• Is biocompatible, biodegradable, and water-soluble polysaccharide
• Demonstrates immunomodulatory activity and mucosal bioadhesion
• Is suitable for oral, topical, nasal, and buccal formulations

Pustulan is extracted and purified from Umbilicaria lichen species, yielding a linear glucan structure with β-(1→6) glycosidic linkages. Its unique structure distinguishes it from other β-glucans and provides a characteristic profile of solubility, rheology, and immune interaction that is valued in mucosal and bioactive pharmaceutical platforms.

In pharmaceutical development, Pustulan is used in:

• Bioadhesive formulations for nasal, buccal, and vaginal delivery systems to enhance residence time and absorption
• Topical wound healing preparations where it supports moisture retention and provides a protective, film-forming matrix
• Immunomodulatory adjuvant systems, particularly in combination with vaccine antigens or oral biologics
• Hydrogel or matrix systems as a slow-release carrier for peptides or small molecules

Preclinical studies suggest Pustulan’s potential role in activating innate immune responses (e.g., macrophage and dendritic cell stimulation), supporting its use as a pharmaceutical excipient with biological function. Its mild, non-irritating profile also makes it suitable for sensitive applications, including pediatric and geriatric formulations.

CarboMer supplies pharmaceutical-grade Pustulan with high purity and molecular weight control. The material is delivered as a white to off-white powder that is characterized by high solubility in aqueous systems.

Packaging is available in sealed, moisture-controlled containers, ranging from research quantities to commercial-scale bulk. Minimum order quantities (MOQ), lead times, and full regulatory documentation (CoA, SDS, technical file) are available upon request.

Each batch undergoes analytical testing for molecular weight distribution, β-linkage confirmation, solubility, endotoxins, heavy metals, and microbial purity, ensuring batch-to-batch consistency and compliance with pharmaceutical development standards.

As with all CarboMer excipients, Pustulan is supported by expert technical consultation, regulatory assistance, and formulation guidance to help clients develop differentiated, effective, and biologically relevant drug delivery platforms.