Description

Propafenone HCl

Propafenone HCl is a high-purity antiarrhythmic agent used in pharmaceutical formulations to manage cardiac arrhythmias, including atrial fibrillation and ventricular tachycardia. As a class 1C sodium channel blocker, it stabilizes cardiac electrical activity, prolongs conduction, and suppresses abnormal heart rhythms. The hydrochloride salt enhances solubility, formulation stability, and bioavailability in oral and injectable dosage forms. Propafenone
• Is an antiarrhythmic agent for management of atrial and ventricular arrhythmias
• Stabilizes cardiac electrical activity and suppresses abnormal heart rhythms
• Is used in oral tablets, capsules, and parenteral solutions
• Is suitable for acute and chronic therapy in cardiac care
• Is manufactured under Good Manufacturing Practice (GMP) conditions
• Is supplied with complete regulatory documentation including Certificate of Analysis (CoA) and technical data
Propafenone HCl is chemically designated as 1-[2-Hydroxy-3-(propylamino)propyl]-3-phenylpropan-1-one hydrochloride. It appears as a white to off-white crystalline powder that is freely soluble in water and compatible with a variety of formulation excipients. Its pharmacological activity primarily arises from sodium channel blockade, with secondary beta-blocking effects contributing to its antiarrhythmic efficacy.
In pharmaceutical applications, Propafenone HCl is used in:
• Oral tablets and capsules for long-term management of atrial fibrillation and flutter
• Injectable solutions for acute ventricular arrhythmia treatment
• Combination therapies where modulation of cardiac conduction is required
• Research and development of cardiovascular pharmacology formulations
Propafenone HCl demonstrates predictable absorption, distribution, and metabolism, allowing consistent therapeutic effects. Its stability and solubility make it suitable for both hospital and outpatient settings under medical supervision.
CarboMer supplies Propafenone HCl with control over assay, particle size, polymorphic form, residual solvents, and microbial content. The material is suitable for pharmaceutical use and formulation development.
The product is packaged in sealed, moisture-protective, tamper-evident containers. Available in laboratory, pilot, and commercial-scale quantities. Minimum order quantities (MOQ), lead times, and documentation including CoA and SDS are provided upon request.
Each batch is tested for identity (IR, HPLC), assay, residual solvents, heavy metals, and microbial purity. Certificates of Analysis (CoA), Safety Data Sheets (SDS), and full traceability documentation accompany every shipment.
As with all CarboMer cardiovascular APIs, Propafenone HCl is supported by formulation expertise, regulatory guidance, and secure global supply to help ensure the development of safe, effective, and high-quality antiarrhythmic products.