Description

Progesterone USP

Progesterone USP is a pharmaceutical-grade, naturally occurring Progestin used in hormone replacement therapy (HRT), fertility treatments, and the formulation of oral, topical, and parenteral medications. With well-characterized bioactivity and excellent safety profile, it plays a critical role in reproductive health, menstrual regulation, and pregnancy support. Progesterone

• Is a USP-compliant active pharmaceutical ingredient (API)
• Is a bioidentical progestin with broad use in reproductive health and endocrine therapy
• Is suitable for oral capsules, transdermal gels, vaginal inserts, and intramuscular injections
• Is available as a high-purity, micronized form that enhances bioavailability in oral and topical formulations

Progesterone (Pregn-4-ene-3,20-dione) is a steroid hormone essential for ovulation, endometrial regulation, embryo implantation, and pregnancy maintenance. In pharmaceutical formulations, it is used as monotherapy or in combination with estrogens for postmenopausal hormone therapy, and in assisted reproductive technology (ART) protocols to support luteal function.

In pharmaceutical development, Progesterone USP is used in:

• Hormone replacement therapy (HRT) to manage menopausal symptoms and protect the endometrium when combined with estrogens
• Fertility treatments such as IVF, to support luteal phase and early pregnancy
• Dysfunctional uterine bleeding, amenorrhea, and endometrial hyperplasia treatment
• Oral softgel capsules, transdermal creams, vaginal suppositories, and injectable formulations

Micronized Progesterone improves dissolution and absorption in oral delivery, allowing therapeutic plasma concentrations with fewer side effects. Its bioidentical structure (chemically identical to endogenous human progesterone) makes it well tolerated with minimal androgenic or estrogenic activity.

CarboMer supplies Progesterone USP with tight control over particle size, polymorphic form, and residual solvents to ensure optimal bioavailability and batch-to-batch consistency. The material is produced in accordance with the U.S. Pharmacopeia monograph, ensuring regulatory alignment and quality assurance.

Packaging is available in moisture-controlled, tamper-evident containers suitable for R&D, pilot, and commercial-scale use. Minimum order quantities (MOQ), lead times, and full regulatory documentation are available upon request, including CoA and SDS.

Each batch undergoes rigorous testing for identity, assay, residual solvents, heavy metals, microbial contamination, and polymorphic consistency to ensure full compliance with USP standards and regulatory requirements.

As with all CarboMer APIs, Progesterone USP is supported by formulation consultation, regulatory assistance, and lifecycle management services to ensure your product development is successful, efficient, and globally compliant.