Description

Procarbazine HCl

Procarbazine HCl is a pharmaceutical-grade alkylating agent used in oral oncology formulations for the treatment of Hodgkin’s lymphoma and other malignant lymphomas. As a hydrazine derivative, it interferes with DNA synthesis and repair, exerting cytotoxic effects that contribute to its antineoplastic activity. Procarbazine HCl

• Is a pharmaceutical-grade active pharmaceutical ingredient (API)
• Is an alkylating agent indicated for use in Hodgkin’s lymphoma and other lymphoid malignancies
• Is suitable for solid oral dosage forms including capsules and tablets
• Is a water-soluble hydrochloride salt for consistent absorption and bioavailability

Procarbazine HCl (a Methylhydrazine derivative) is an antineoplastic agent that undergoes metabolic activation in vivo to produce reactive methylating species that alkylate DNA, leading to disruption of nucleic acid function and apoptosis in rapidly dividing cells. It is a key component of combination chemotherapy regimens such as MOPP (Mechlorethamine, Vincristine, Procarbazine, Prednisone) for Hodgkin’s disease.

In pharmaceutical development, Procarbazine HCl is used in:

• Oral chemotherapy formulations for Hodgkin’s lymphoma and non-Hodgkin’s lymphomas
• Combination antineoplastic regimens in both first-line and relapsed/refractory settings
• Investigational protocols for gliomas and other CNS tumors due to its ability to cross the blood-brain barrier

Due to its potent mechanism and narrow therapeutic index, Procarbazine formulations require careful control over content uniformity, stability, and handling during development and manufacturing. It is typically delivered as a capsule to ensure accurate dosing and patient convenience.

CarboMer supplies Procarbazine HCl with strict control over impurities, particle size, residual solvents, and microbial limits, ensuring consistent quality and performance. Our API complies with all applicable pharmacopeial monographs and regulatory standards for oncology products.

The material is packaged in sealed, light-resistant, tamper-evident containers to preserve potency and stability. Available in R&D, pilot, and commercial-scale quantities. Minimum order quantities (MOQ), lead times, and complete regulatory documentation are provided to support global development and submission.

Each batch undergoes validated testing for identification, assay, related substances, heavy metals, and microbiological purity, and is delivered with full traceability and documentation support.

As with all CarboMer APIs, Procarbazine HCl is supported by technical formulation guidance, regulatory expertise, and lifecycle management services to ensure your oncology product development is efficient, compliant, and market-ready.