Description

Procaine Hydrochloride USP

Procaine Hydrochloride USP is a high-purity, pharmaceutical-grade local anesthetic widely used in injectable formulations for regional and infiltration anesthesia. As an ester-type anesthetic, it provides rapid onset and moderate duration of action, making it a preferred choice for dental, surgical, and obstetric procedures requiring reversible nerve blockade. Procaine Hydrochloride

• Is a USP-compliant active pharmaceutical ingredient (API)
• Is an ester-type local anesthetic with fast onset and moderate duration
• Is suitable for injectable solutions (infiltration, nerve block, spinal anesthesia)
• Ensures rapid absorption as a water-soluble hydrochloride salt and allows precise dosing

Chemically known as 2-(Diethylamino)ethyl 4-aminobenzoate hydrochloride, Procaine HCl works by blocking voltage-gated sodium channels in nerve membranes, thereby inhibiting nerve impulse conduction. Its reversible anesthetic action is confined to the site of administration, with systemic absorption depending on dose, concentration, and vascularity of the tissue.

In pharmaceutical formulations, Procaine Hydrochloride USP is used in:

• Local and regional anesthetic injections for dental, minor surgical, and obstetric procedures
• Spinal anesthesia in low-concentration solutions for lower body surgeries
• Infiltration anesthesia for soft tissue procedures where limited duration is acceptable
• Adjunctive preparations with vasoconstrictors (e.g., epinephrine) to prolong anesthetic effect and minimize systemic absorption

Due to its ester linkage, Procaine is rapidly hydrolyzed by plasma esterases, reducing systemic toxicity and shortening its half-life. This pharmacokinetic profile makes it well-suited for outpatient procedures and short-acting applications.

CarboMer supplies Procaine Hydrochloride USP with tightly controlled purity, particle size, and residual solvent limits to ensure batch-to-batch reproducibility and formulation compatibility.

The material is packaged in sealed, light- and moisture-protected containers for safe storage and transport. Available in research, pilot, and commercial-scale pack sizes. Minimum order quantities (MOQ), lead times, and full regulatory support documentation—including CoA and SDS are provided to support formulation, validation, and global registration.

Each batch is tested against USP specifications for identification, assay, related substances, pH, solubility, and microbiological quality. Certificates of Analysis (CoA) accompany every shipment.

As with all CarboMer APIs, Procaine Hydrochloride USP is fully supported by formulation guidance, regulatory consultation, and quality documentation to help you advance safe, compliant local anesthetic products from development to market.