Description

Procainamide HCl USP

Procainamide Hydrochloride USP is a high-purity, pharmaceutical-grade antiarrhythmic agent used in oral and parenteral drug formulations for the treatment of ventricular and supraventricular arrhythmias. As a sodium channel blocker classified under Class 1A antiarrhythmics, it modifies cardiac conduction by prolonging the action potential and refractory period of myocardial tissue. Procainamide HCl

• Is a USP-compliant active pharmaceutical ingredient (API)
• Is a Class 1A antiarrhythmic agent effective in managing atrial and ventricular arrhythmias
• Is available for oral and injectable formulations (e.g., tablets, capsules, IV solutions)
• Is available as a water-soluble hydrochloride salt form for efficient systemic delivery

Chemically known as the hydrochloride salt of 4-Amino-N-[2-(diethylamino)ethyl]benzamide, Procainamide HCl works by inhibiting phase 0 depolarization in cardiac myocytes, reducing conduction velocity and prolonging repolarization. This mechanism makes it effective in suppressing both atrial fibrillation and life-threatening ventricular arrhythmias, including ventricular tachycardia.

In pharmaceutical development, Procainamide HCl USP is used in:

• Oral formulations (immediate and extended-release tablets) for chronic outpatient arrhythmia management
• Injectable preparations for acute, hospital-based treatment of life-threatening ventricular arrhythmias
• Fixed-dose combination therapies with other cardiovascular agents for enhanced control of cardiac rhythm

Its high water solubility in the Hydrochloride salt form enables rapid absorption and formulation flexibility for IV and oral dosage forms. Formulation scientists often tailor release kinetics to achieve therapeutic plasma concentrations while minimizing the risk of proarrhythmia and toxicity.

Pharmaceutical manufacturers and formulators seeking to purchase Procainamide HCl USP benefit from CarboMer’s rigorous quality control, tight impurity limits, and robust regulatory support for global submissions.

The material is supplied in sealed, light-resistant, moisture-controlled packaging to preserve integrity during storage and transport. Standard and bulk pack sizes are available, with minimum order quantities (MOQ) and lead times structured to support both development and commercial production.

Each batch is tested per USP monograph requirements for identity, potency, impurities, pH, solubility, and microbial limits. Full traceability and Certificates of Analysis (CoA) upon request.

As with all CarboMer APIs, Procainamide HCl USP is supported by end-to-end technical consulting, regulatory documentation, and formulation assistance helping innovators bring safe, effective, and compliant cardiovascular therapies to market.