Description

Probucol USP

Probucol USP is a pharmaceutical-grade lipid-lowering agent used in oral drug formulations for the treatment of hypercholesterolemia and oxidative stress-associated conditions. With its potent antioxidant properties and ability to reduce low-density lipoprotein (LDL) cholesterol, Probucol is incorporated in both monotherapy and adjunctive lipid management strategies. Probucol

• Is a USP-compliant active pharmaceutical ingredient (API)
• Is a lipid-lowering agent that reduces total and LDL cholesterol
• Exhibits antioxidant properties; it scavenges free radicals and inhibits LDL oxidation
• Is suitable for solid oral dosage forms including tablets and capsules

Chemically known as a Bis(4-hydroxyphenyl)propane disulfide derivative, Probucol is a lipophilic compound that lowers serum cholesterol levels by increasing the catabolism of LDL particles and reducing cholesterol synthesis. Its antioxidant mechanism protects lipoproteins from oxidative modification, contributing to its therapeutic effect in atherosclerotic conditions.

In pharmaceutical development, Probucol USP is used in:

• Oral lipid-lowering medications targeting familial hypercholesterolemia or combined hyperlipidemia
• Adjunctive therapy with statins or bile acid sequestrants for patients with mixed lipid profiles
• Formulations aimed at oxidative stress modulation where its antioxidant properties may benefit vascular or metabolic health

Due to its poor aqueous solubility, formulation strategies often involve solid dispersion techniques, lipid-based carriers, or micronization to enhance bioavailability. Probucol is typically formulated in tablets or hard gelatin capsules and may be combined with other lipid-regulating agents in fixed-dose combinations.

CarboMer supplies Probucol USP with tight control over purity, particle size, and residual solvents to ensure consistency in bioavailability and performance. Each production lot undergoes validated testing for identification, assay, impurities, heavy metals, and microbiological quality per USP specifications.

The material is packaged in sealed, light-resistant, tamper-evident containers and is available in research and bulk quantities. Minimum order quantities (MOQ), lead times, and full regulatory support documentation are available to support formulation development, scale-up, and global submission.

As with all CarboMer APIs, Probucol USP is supported by expert formulation consultation, technical guidance, and regulatory documentation empowering formulators to efficiently develop safe, effective and compliant lipid-lowering therapies.