Description

Polysucrose 400

Polysucrose 400 is a high-purity, synthetic, nonionic polymer widely used as a density gradient medium and stabilizing agent in pharmaceutical, biologic, and cell therapy formulations. With its excellent biocompatibility, defined molecular weight, and consistent osmotic properties, Polysucrose 400 is essential for isopycnic separation of cells and subcellular components and for stabilizing sensitive biologics. Polysucrose 400

• Is a synthetic, nonionic copolymer of sucrose and epichlorohydrin
• Has a high molecular weight (~400 kDa) and is highly water-soluble and non-toxic
• Is used for cell and virus separation, protein purification, and biologic stabilization
• Is biocompatible and osmotically inert—it does not penetrate cell membranes

Polysucrose 400 is commonly used to create density gradients in ultracentrifugation or separation protocols, where it enables high-resolution fractionation of cells, viruses, organelles, and macromolecules under physiologically compatible conditions. Its inert nature and low endotoxin profile make it suitable for use in clinical and GMP-grade bioprocessing environments.

In pharmaceutical and biologic applications, Polysucrose 400 is used as:

• A density gradient medium for isolating lymphocytes, islets, tumor cells, and viruses from blood or tissue suspensions
• A stabilizer for proteins, nucleic acids, and viral vectors during purification and formulation
• A cryoprotective component in cell preservation and transport media
• A component in biologic excipient systems where high molecular weight polymers are used to regulate viscosity or provide colloidal stability

Pharmaceutical, biotechnology and cell therapy developers seeking to purchase Polysucrose 400 benefit from CarboMer’s consistent quality manufacturing processes, validated analytical methods, and complete regulatory support to enable global development and regulatory submissions.

The material is supplied as a white to off-white powder or granular solid, packaged in sealed, moisture-controlled containers. Available in standard research packs and bulk quantities for GMP manufacturing. Minimum order quantities (MOQ), lead times, and full technical support are provided upon request.

Each batch is fully tested, ensuring it meets stringent pharmaceutical and biologic quality standards.

As with all CarboMer polymers and excipients, Polysucrose 400 is fully supported by expert technical consultation, regulatory documentation, and lifecycle development services helping innovators advance therapeutic platforms and achieve regulatory success.