Description

Poly(styrenesulfonic acid) Sodium Salt

Poly(styrenesulfonic acid) sodium salt (PSA) is a high-purity, pharmaceutical-grade polyanionic polymer widely utilized in drug delivery, controlled-release formulations, ion-exchange systems, and advanced biomedical applications. Its strong ionic charge density, biocompatibility, and aqueous solubility support multiple pharmaceutical functions, including ionic complexation, stabilization, and release modulation. PSA

• Is a pharmaceutical-grade anionic polyelectrolyte with strong sulfonic acid functionality
• Has high water solubility and stability across a wide pH range
• Offers efficient cation binding capacity for controlled-release drug delivery systems
• Is fully biocompatible and widely recognized for pharmaceutical and biomedical applications

Poly(styrenesulfonic acid) sodium salt consists of styrene monomers with sulfonic acid groups substituted onto the aromatic ring, neutralized by sodium ions. This structure provides a permanently charged anionic polymer capable of forming stable complexes with a wide range of positively charged molecules, including cationic drugs, peptides, proteins, and metal ions. Its ionic strength remains constant across formulation pH ranges due to the strong acidity of the sulfonic group.

In pharmaceutical controlled-release applications, Poly(styrenesulfonic acid) sodium salt is used to form ion-exchange complexes with cationic active pharmaceutical ingredients (APIs), prolonging drug release by modulating ion exchange kinetics. It is utilized in oral dosage forms, microsphere formulations, and implantable depots, delivering APIs over extended durations while maintaining drug stability.

In ophthalmic, nasal, and mucosal drug delivery, this polymer’s bioadhesive and ionic interaction properties enhance residence time, promote localized drug retention, and optimize absorption. Poly(styrenesulfonic acid) sodium salt is also employed in nanoparticle and polyelectrolyte multilayer systems to stabilize colloidal dispersions and protect sensitive APIs from aggregation or degradation.

Biomedical developers and pharmaceutical formulators seeking to purchase Poly(styrenesulfonic acid) sodium salt benefit from CarboMer’s stringent production controls, narrow molecular weight distribution, consistent sulfonation degree, and comprehensive regulatory documentation to support global development programs.

Material is supplied in sealed, moisture-protected, tamper-evident containers to ensure product stability. Minimum order quantities (MOQ), lead times, and full regulatory support packages are available for both clinical development and commercial-scale production.

Each batch undergoes validated analytical testing for molecular weight distribution, degree of sulfonation, residual monomers, heavy metals, and microbial purity to ensure reproducibility and full regulatory compliance.

As with all CarboMer excipients and delivery polymers, Poly(styrenesulfonic acid) sodium salt is fully supported by expert formulation consultation, technical development assistance, and regulatory expertise to streamline product development and facilitate global regulatory submissions.