Description

Polyquaternium 22

Polyquaternium 22 is a high-purity, ampholytic copolymer that functions as a film-former, stabilizer, and conditioning agent in pharmaceutical, biomedical, and personal care formulations. Its unique balance of cationic and anionic charges allows it to interact with both hydrophilic and hydrophobic molecules, improving bioadhesion, stability, and formulation flexibility across multiple dosage forms. Polyquaternium 22

• Is an ampholytic polymer combining quaternary ammonium and carboxylic acid functionalities
• Has excellent film-forming, bioadhesive, and stabilization properties
• Supports controlled release, mucosal retention, and emulsion stabilization
• Is fully biocompatible for use in oral, ophthalmic, mucosal, transdermal, and topical applications

Polyquaternium 22 is a copolymer of Diallyldimethylammonium chloride and acrylic acid. The combination of strong cationic charge (from quaternary ammonium groups) and hydrophilic anionic functionality (from carboxyl groups) allows for excellent interaction with biological tissues, mucins, and both positively and negatively charged drug substances.

In pharmaceutical and biomedical formulations, Polyquaternium 22 is used as:

• A mucoadhesive agent in nasal, buccal, ophthalmic, vaginal, and rectal delivery platforms, increasing residence time and improving absorption
• A stabilizer for emulsions, suspensions, and nanoparticle delivery systems
• A controlled-release excipient for solid oral dosage forms by forming ionic complexes with active pharmaceutical ingredients
• A film-former in topical creams, gels, and transdermal delivery patches, improving mechanical stability, flexibility, and uniformity

In personal care formulations, Polyquaternium 22 provides excellent conditioning properties, enhancing feel, spreadability, antistatic effects, and moisture retention in hair care, skin care, and cosmetic products.

Pharmaceutical developers and procurement teams seeking to purchase Polyquaternium 22 benefit from CarboMer’s strict molecular weight control, validated manufacturing processes, and global regulatory documentation, ensuring confidence in its pharmaceutical and biomedical use.

The product is packaged in sealed, moisture-protected containers to preserve product quality during storage and shipment. Minimum order quantities (MOQ), lead times, and full technical documentation packages are available for both clinical development and commercial manufacturing.

Each production batch undergoes validated testing for molecular weight, nitrogen content, residual monomers, heavy metals, and microbial contamination to ensure full regulatory compliance and reproducibility.

As with all CarboMer excipients and specialty polymers, Polyquaternium 22 is fully supported by expert formulation consultation, regulatory assistance, and technical development services, enabling clients to advance drug development projects efficiently from early-stage development to global registration.