Description

Polyquaternium-1

Polyquaternium-1 is a high-purity, low molecular weight quaternary ammonium polymer widely used as a preservative and antimicrobial agent in ophthalmic, pharmaceutical, and biomedical formulations. Its excellent antimicrobial efficacy, combined with superior ocular tolerability, makes it a preferred preservative in multi-dose ophthalmic solutions and advanced drug delivery systems.

• Pharmaceutical-grade, cationic quaternary ammonium polymer
• Effective preservative and antimicrobial agent for ophthalmic and mucosal formulations
• Low toxicity profile and excellent ocular surface compatibility
• Fully water-soluble for easy incorporation into aqueous drug delivery systems

Polyquaternium-1 is a polymeric quaternary ammonium compound, typically supplied as an aqueous solution, known for its broad-spectrum antimicrobial activity against bacteria, fungi, and common ocular pathogens. Unlike traditional preservatives such as benzalkonium chloride, Polyquaternium-1 offers a significantly improved safety and tolerability profile, minimizing corneal and conjunctival irritation, making it highly suitable for chronic ophthalmic use.

In pharmaceutical and ophthalmic applications, Polyquaternium-1 is widely used as:

• A preservative in multi-dose ophthalmic formulations, including eye drops for glaucoma, dry eye disease, allergy treatments, and anti-inflammatory therapies
• An antimicrobial agent in nasal, mucosal, and topical formulations where sterility assurance and long-term stability are required
• A stabilizer in ophthalmic drug delivery systems, contact lens solutions, and ocular surface treatments due to its excellent compatibility with sensitive tissues
• A preservative option for biologic formulations requiring gentle antimicrobial protection without compromising protein stability or epithelial tolerance

Pharmaceutical formulators and procurement teams seeking to purchase Polyquaternium-1 benefit from CarboMer’s tightly controlled manufacturing processes, validated analytical methods, and comprehensive global regulatory documentation to support both clinical and commercial ophthalmic product development.

Material is supplied in sealed, tamper-evident, sterile or non-sterile aqueous packaging to maintain long-term integrity. Minimum order quantities (MOQ), lead times, and full regulatory support documentation are available for development, clinical trials, and global registration.

Each production batch undergoes validated quality control testing, including identity, purity, active content, residual impurities, and microbial purity, ensuring reproducibility and full regulatory compliance for ophthalmic and parenteral use.

As with all CarboMer excipients and specialty polymers, Polyquaternium-1 is fully supported by technical formulation guidance, regulatory assistance, and lifecycle management services to accelerate ophthalmic and mucosal drug development programs toward global commercialization.