Description

Poly(3-hydroxybutyrate-co-3-hydroxyvalerate)

Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) is a biocompatible, biodegradable copolymer engineered for advanced drug delivery systems, implantable devices, and tissue engineering applications. Its adjustable degradation profile, excellent biocompatibility, and mechanical flexibility make it a highly versatile excipient and biomaterial for regulated pharmaceutical and biomedical product development.

• It is a pharmaceutical-grade biodegradable polyhydroxyalkanoate (PHA) copolymer
• It has enhanced flexibility and controlled degradation compared to the homopolymer PHB
• It supports long-acting injectables, drug-eluting implants, microspheres, and scaffolds
• It is fully biocompatible with predictable in vivo degradation into non-toxic byproducts

PHBV is synthesized through microbial fermentation, incorporating varying molar ratios of 3-Hydroxybutyrate (3HB) and 3-Hydroxyvalerate (3HV) monomers. The 3HV component imparts enhanced flexibility, processability, and modulated degradation rates, making PHBV ideal for customized sustained-release drug delivery applications and implantable therapeutic platforms.

In pharmaceutical applications, Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) is utilized as a matrix former for long-acting injectable depots, microsphere-based controlled release systems, implantable drug delivery devices, and solid implantable scaffolds. Its predictable hydrolytic degradation produces biocompatible metabolites that are naturally metabolized by the body, reducing the need for device removal.

In regenerative medicine and biomedical engineering, PHBV is valued for use in tissue scaffolds, sutures, wound dressings, and orthopedic devices, where its mechanical strength, flexibility, and biocompatibility enable integration with host tissue and promote healing.

Pharmaceutical companies and biomedical developers looking to purchase Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) benefit from CarboMer ’s reliable GMP-compliant production, material consistency, and comprehensive regulatory documentation. Multiple molecular weight and composition grades are available to support both research and commercial-scale manufacturing.

PHBV is packaged in tamper-evident containers to protect product integrity during storage and transportation. Minimum order quantities (MOQ), lead times, and complete regulatory data packages are provided to facilitate global development and registration processes.

Each lot undergoes validated analytical testing for molecular weight profile, copolymer composition (3HV content) and other specifications to meet strict standards.

As with all CarboMer biomaterials and excipients, Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) is supported by technical expertise, formulation consultation, and regulatory assistance, ensuring smooth integration into regulated drug development and biomedical programs worldwide.