Description

Poloxamer 407

Poloxamer 407 is a high-purity, nonionic surfactant and thermoresponsive polymer used extensively in pharmaceutical formulations for its solubilizing, emulsifying, and gel-forming capabilities. Its unique amphiphilic block copolymer structure allows it to stabilize complex formulations and improve the solubility and bioavailability of poorly water-soluble compounds. It

• Is a NF-grade, pharmaceutical-quality block copolymer
• Exhibits thermoreversible gelation properties
• Functions as a solubilizer, emulsifier, viscosity modifier, and sustained-release agent
• Is compatible with oral, ophthalmic, parenteral, topical, and mucosal delivery systems

Poloxamer 407, also known as Pluronic® F127, is composed of polyethylene oxide (PEO) and Polypropylene oxide (PPO) blocks arranged in a PEO-PPO-PEO configuration. This architecture allows it to form micelles in aqueous systems and create temperature-sensitive gels, making it highly versatile for controlled-release and in-situ gel formulations.

In parenteral and ophthalmic formulations, Poloxamer 407 serves as a solubilizing agent for poorly soluble APIs and stabilizes emulsions and suspensions. Its thermoreversible gelation allows for injectable depot systems, ocular gels, and nasal sprays that gel at body temperature, enhancing residence time and patient compliance. In topical and transdermal products, it provides excellent spread ability, hydration, and drug delivery performance.

Pharmaceutical manufacturers, formulation scientists, and procurement professionals seeking to buy Poloxamer 407 can rely on CarboMer for consistent manufacturing, comprehensive regulatory support, and technical expertise. Material is available in multiple packaging sizes to support both R&D and commercial-scale production.

Poloxamer 407 is packaged in tamper-evident, moisture-controlled containers to preserve material integrity. Minimum order quantities (MOQ), lead times, and complete regulatory data packages are available upon request to facilitate streamlined procurement and regulatory submissions.

Each production lot is rigorously tested to meet or exceed NF standards for identity, molecular weight distribution, residual solvents, and microbial safety. CarboMer ’s manufacturing processes ensure reliable batch-to-batch consistency, full traceability, and global regulatory compliance.

As with all CarboMer excipients, Poloxamer 407 is supported by end-to-end technical consulting, regulatory assistance, and lifecycle management empowering clients to confidently advance product development from formulation through commercial launch.