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Poloxamer 407 NF

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SKU: 8-01155 Category: Tag:

Description

Poloxamer 407 NF

Poloxamer 407 NF is a nonionic block copolymer surfactant widely used in pharmaceutical and biopharmaceutical formulations for its solubilizing, emulsifying, and thermoresponsive gel-forming properties. Its amphiphilic structure supports micellization, drug solubilization, and formulation stabilization across multiple delivery systems. It

  • is a National Formulary (NF)-grade, pharmacopeial-compliant excipient
  • features thermoreversible gelation at physiological temperatures
  • is an effective solubilizer and emulsifier for poorly soluble active pharmaceutical ingredients (APIs)
  • is suitable for oral, ophthalmic, topical, parenteral, and mucosal applications

Poloxamer 407 NF is composed of polyethylene oxide (PEO) and polypropylene oxide (PPO) arranged in a PEO-PPO-PEO structure. This configuration allows for micelle formation, improving solubility and stability of hydrophobic APIs. The polymer’s thermoresponsive behavior enables in-situ gelation, forming viscous gels upon exposure to body temperature — a feature utilized in ophthalmic gels, injectable depots, nasal sprays, and controlled-release systems.

In parenteral formulations, Poloxamer 407 NF enhances solubility and stability for sensitive APIs while minimizing irritation. In ophthalmic products, it extends ocular residence time by gelling at ocular surface temperatures. In topical and transdermal applications, it enhances spread ability, skin absorption, and patient compliance while maintaining formulation integrity.

Pharmaceutical companies and procurement professionals seeking to purchase Poloxamer 407 NF benefit from CarboMer ’s consistent production quality, batch reproducibility, and comprehensive regulatory documentation. Material is available in scalable packaging configurations to support development through commercial manufacturing.

Poloxamer 407 NF is supplied in sealed, moisture-controlled containers to ensure long-term stability. Minimum order quantities (MOQ), lead times, and full regulatory documentation are available to streamline development and registration processes globally.

Each production batch is tested per NF specifications, including molecular weight profile, residual solvents, and microbiological safety, ensuring lot-to-lot consistency. CarboMer ’s validated manufacturing processes provide full traceability, regulatory compliance, and global supply assurance.

As with all CarboMer excipients, Poloxamer 407 NF is supported by expert formulation consultation, regulatory guidance, and full technical support throughout the product lifecycle.

Additional information

Dimensions 1 × 1 × 1 cm