Description

Poloxamer 338 NF

Poloxamer 338 NF is a high molecular weight nonionic surfactant and solubilizer used in pharmaceutical, biotechnology, and cosmetic formulations. Its amphiphilic block copolymer structure offers exceptional solubilization, emulsification, and stabilization for a wide range of active pharmaceutical ingredients and complex delivery systems. It

• Is a NF-grade, pharmacopeial-compliant Poloxamer
• Has a high hydrophilic-lipophilic balance (HLB) for enhanced solubility and stabilization
• Functions as solubilizer, emulsifier, and viscosity modifier
• Is compatible with oral, ophthalmic, parenteral, topical, and biopharmaceutical formulations

Poloxamer 338 consists of Polyethylene oxide (PEO) and Polypropylene oxide (PPO) blocks, with a significantly higher PEO content compared to other Poloxamers. This elevated hydrophilic content makes it highly effective at solubilizing hydrophobic drugs in aqueous systems, stabilizing emulsions, and improving the bioavailability of poorly soluble compounds.

In oral and parenteral formulations, Poloxamer 338 NF assists in creating stable micellar systems that enhance drug solubilization and protect sensitive APIs from degradation. It is widely used in intravenous solutions, protein stabilization, controlled-release systems, ophthalmic preparations, and dermal formulations. Its nonionic nature reduces irritation risk and improves biocompatibility across diverse applications.

Pharmaceutical manufacturers, formulators, and procurement teams seeking to purchase Poloxamer 338 NF benefit from CarboMer’s consistent manufacturing quality, validated analytical methods, and comprehensive regulatory support. Material is available in scalable packaging configurations to support early development through commercial-scale manufacturing.

Poloxamer 338 NF is supplied in tamper-evident, moisture-protected containers to preserve product quality. Minimum order quantities (MOQ), lead times, and complete technical documentation are available to support both development timelines and regulatory submissions.

Each batch is rigorously tested to meet NF specifications for identity, molecular weight profile, residual solvents, and microbial purity. CarboMer’s validated processes ensure batch-to-batch reproducibility, full traceability, and global regulatory compliance.

As with all CarboMer excipients, Poloxamer 338 NF is backed by expert formulation consulting, regulatory support, and lifecycle management to help clients accelerate product development while meeting global compliance standards.