Description

Poloxamer 188

Poloxamer 188 is a versatile nonionic surfactant and solubilizing agent used in a wide range of pharmaceutical, biopharmaceutical, and medical device applications. It is valued for its gentle surface activity and biocompatibility.

• It is a high-purity PEG-PPG-PEG block copolymer
• It enhances solubility and stability of lipophilic actives
• It reduces protein aggregation and surface adsorption
• It is used in injectable, ophthalmic, oral, and topical dosage forms
• It is manufactured under cGMP-certified conditions
• It is supplied with complete regulatory documentation

Poloxamer 188 is frequently employed in biologics and protein formulations to stabilize sensitive APIs during manufacturing, storage, and administration. It also improves flow characteristics in injectables and enhances drug absorption in poorly water-soluble actives.

Due to its low toxicity and nonirritating profile, it is suitable for parenteral use, ophthalmic solutions, and controlled-release systems. It also finds use in cryopreservation and cell therapy manufacturing.

CarboMer supplies Poloxamer 188 in bulk quantities tailored to formulation needs and regulatory markets. Product is packaged in sealed containers designed for sensitive excipient protection under moisture- and light-controlled conditions.

Each lot is tested according to NF/USP specifications and supported with comprehensive technical files including monograph compliance, impurity profile, and compatibility data.

As with all CarboMer products, Poloxamer 188 is backed by our dedicated technical and regulatory teams—helping ensure your formulation performance and compliance from development through commercialization.