Description

Poloxamer 181 NF

Poloxamer 181 NF is a nonionic surfactant and emulsifying agent used in pharmaceutical, personal care, and industrial applications to stabilize emulsions, enhance solubility, and support drug delivery systems.

• It is compliant with National Formulary (NF) monograph standards
• It is a Polyethylene-polypropylene glycol block copolymer (PEG-PPG-PEG)
• It is a nonionic emulsifier ideal for oil-in-water systems
• It enhances bioavailability and improves physical stability
• It is manufactured in cGMP-certified facilities
• It is supplied with CoA and excipient safety documentation

Poloxamer 181 is a high-molecular-weight amphiphilic compound valued for its versatility in stabilizing emulsions and suspensions. It is used extensively in topical creams, gels, ophthalmic formulations, and oral liquids. Its mild profile and excellent biocompatibility make it suitable for use in sensitive formulations including pediatric and dermal applications.

This excipient reduces surface and interfacial tension, making it a critical component in formulations requiring solubilization of hydrophobic active ingredients. It is also known to contribute to improved drug dissolution and delivery in poorly soluble compounds.

CarboMer supplies Poloxamer 181 NF in bulk quantities with tight control on batch consistency. Material is packaged in sealed, tamper-evident containers optimized for moisture and light protection.

All batches are tested against NF specifications for identity, assay, and heavy metals, and meet criteria for microbial purity and physicochemical performance. Documentation support includes formulation compatibility data, toxicological profile, and compendial status.

As with all CarboMer excipients, Poloxamer 181 NF is backed by our technical formulation support, regulatory expertise, and quality systems to streamline development and support high-performing pharmaceutical and personal care innovations.