Description

Nadroparin Calcium EP

Nadroparin Calcium EP is a high-purity low molecular weight Heparin used in pharmaceutical formulations for the prevention and treatment of thromboembolic disorders. Compliant with European Pharmacopoeia (EP) standards, it is widely used in surgical, medical, and obstetric settings due to its predictable anticoagulant activity and favorable safety profile.
Nadroparin Calcium is produced by controlled depolymerization of Heparin derived from porcine intestinal mucosa, followed by conversion to the Calcium salt to achieve defined molecular weight distribution and activity. It appears as a white to off-white hygroscopic powder that is freely soluble in water, making it suitable for injectable formulations.
In pharmaceutical and clinical applications, Nadroparin Calcium EP is used in:
• Prophylaxis of deep vein thrombosis following surgery or immobilization
• Treatment of acute venous thromboembolism
• Prevention of thrombotic complications in high-risk patients
• Anticoagulation during hemodialysis
• Management of thromboembolic risk during pregnancy
• Clinical research involving anticoagulant therapies
Nadroparin Calcium EP exerts its anticoagulant effect primarily by potentiating antithrombin-mediated inhibition of Factor Xa, with limited activity against thrombin (Factor IIa). This selective activity supports predictable anticoagulation with reduced monitoring requirements compared to unfractionated Heparin.
CarboMer supplies Nadroparin Calcium EP with details of the molecular weight distribution, anti-Xa activity, calcium content, purity, sulfate content, and microbial quality. The material meets EP monograph specifications and is suitable for regulated pharmaceutical manufacturing and clinical use.
The material is packaged in sealed, moisture-protective, tamper-evident containers and handled under controlled conditions. Available in laboratory, pilot, and commercial-scale quantities where permitted. Documentation includes Certificate of Analysis (CoA), Safety Data Sheet (SDS), and complete traceability.
Each batch is tested for identity, anti-Xa potency, molecular weight profile, pH, water content, endotoxins, and microbial limits. Technical support is available to assist with formulation considerations, stability, and regulatory compliance.
As with all CarboMer supplied anticoagulant ingredients, Nadroparin Calcium EP is supported by dependable global supply, rigorous quality control, and expert technical guidance to ensure safe, effective, and compliant pharmaceutical product development.