Description

Meropenem USP Trihydrate

Meropenem Trihydrate USP is a high-purity, broad-spectrum Carbapenem antibiotic used in sterile pharmaceutical formulations for the treatment of severe bacterial infections. As a β-Lactam antibiotic, it inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins, leading to cell lysis. This trihydrate form offers enhanced stability and solubility for use in intravenous and intramuscular formulations. Meropenem Trihydrate is

• A USP-compliant broad-spectrum Carbapenem antibiotic
• Effective against gram-positive, gram-negative, and anaerobic pathogens
• Used in sterile injectable formulations for severe bacterial infections
• Compatible with hospital compounding, lyophilization, and reconstitution processes
• Manufactured under Good Manufacturing Practice (GMP) conditions
• Supplied with complete regulatory documentation including Certificate of Analysis (CoA) and technical data

Meropenem Trihydrate USP is chemically designated as (4R,5S,6S)-3-[[5-(Dimethylcarbamoyl)pyrrolidin-3-yl]thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid trihydrate. It appears as a white to pale yellow crystalline powder and is typically provided as a lyophilized solid for reconstitution in 5% Dextrose or compatible diluents.

In pharmaceutical applications, Meropenem Trihydrate USP is used in:

• Intravenous and intramuscular injections for respiratory, urinary, abdominal, and soft tissue infections
• Empiric therapy in immunocompromised patients and multidrug-resistant infections
• Hospital-administered protocols for sepsis and meningitis
• Pediatric and adult intensive care treatment regimens
• Compounded sterile formulations for clinical use

Meropenem exhibits rapid bactericidal activity with excellent tissue penetration, making it a critical agent for life-threatening infections. Its trihydrate form provides stability during storage and handling, ensuring consistent efficacy in reconstituted solutions.

CarboMer supplies Meropenem Trihydrate USP with validated control over assay, water content, residual solvents, and microbial contamination. Each batch meets United States Pharmacopeia (USP) monograph specifications and is suitable for sterile injectable use.

The material is packaged in sealed, tamper-evident, moisture-resistant containers. Available in research, pilot, and commercial-scale volumes. Minimum order quantities (MOQ), lead times, and documentation—including CoA and SDS—are provided upon request.

Each batch is tested for identity (IR, HPLC), assay (anhydrous basis), water content, residual solvents, related substances, and microbial purity. Certificates of Analysis (CoA), Safety Data Sheets (SDS), and full traceability documentation accompany every shipment.

As with all CarboMer sterile-grade APIs, Meropenem Trihydrate USP is supported by formulation expertise, regulatory guidance, and secure global supply to help ensure reliable access to critical antibacterial therapies.