L-Methyldopa USP

Description

L-Methyldopa USP is a high-purity centrally acting antihypertensive agent used in pharmaceutical formulations for the treatment of hypertension. Compliant with United States Pharmacopeia (USP) standards, it is particularly valued for its long-established clinical use and its role as a preferred antihypertensive therapy during pregnancy.

L-Methyldopa is chemically designated as (S)-2-Amino-3-(3,4-Dihydroxyphenyl)-2-Methylpropanoic acid. It appears as a white to off-white crystalline powder that is sparingly soluble in water and practically insoluble in alcohol, making it suitable for formulation into oral solid dosage forms.

In pharmaceutical and clinical applications, L-Methyldopa USP is used in:

• Oral tablets for management of mild to moderate hypertension
• Treatment of hypertension during pregnancy
• Long-term blood pressure control in selected patient populations
• Combination anti-hypertensive therapy regimens
• Research involving central adrenergic and sympathetic regulation

L-Methyldopa USP functions as a prodrug that is metabolized in the central nervous system to A-Methylnorepinephrine. This active metabolite stimulates central alpha-2 adrenergic receptors, reducing sympathetic outflow and lowering peripheral vascular resistance, resulting in decreased blood pressure.

CarboMer supplies L-Methyldopa USP with assay, purity, residual solvents, particle size, and microbial quality. The material meets USP monograph specifications and is suitable for regulated pharmaceutical manufacturing.

The material is packaged in sealed, moisture-resistant, tamper-evident containers and protected from excessive light. Available in laboratory, pilot, and commercial-scale quantities. Documentation includes Certificate of Analysis (CoA), Safety Data Sheet (SDS), and full traceability.

Each batch is tested for identity (IR, HPLC), assay on anhydrous basis, impurity profile, water content, and microbial limits. Technical support is available to assist with formulation development and regulatory compliance.

As with all CarboMer supplied cardiovascular active ingredients, L-Methyldopa USP is supported by dependable global supply, stringent quality control, and expert technical guidance to ensure safe, effective, and consistent pharmaceutical product development.