Description

Estriol USP

Estriol USP is a high-purity endogenous estrogen used in pharmaceutical formulations for hormone therapy applications, particularly in the management of menopausal and postmenopausal symptoms. Compliant with United States Pharmacopeia (USP) standards, it is considered a weaker estrogen compared to Estradiol and Estrone, offering a favorable safety and tolerability profile for localized and systemic therapies.
Estriol is chemically designated as Estra-1,3,5(10)-triene-3,16α,17β-triol. It appears as a white to off-white crystalline powder that is practically insoluble in water but soluble in alcohol and other organic solvents. Its physicochemical properties make it suitable for formulation into creams, gels, vaginal preparations, and oral dosage forms.
In pharmaceutical and clinical applications, Estriol USP is used in:
• Vaginal creams, tablets, and suppositories for urogenital atrophy
• Hormone replacement therapy formulations
• Topical and transdermal estrogen products
• Gynecological and menopausal health treatments
• Research involving estrogen receptor modulation and endocrine regulation
Estriol USP exerts its pharmacological effect by binding to estrogen receptors, helping to restore estrogen activity in estrogen-deficient tissues. Due to its lower receptor affinity and shorter duration of action, it is often selected for localized therapy with reduced systemic exposure.
CarboMer supplies Estriol USP with details of assay, purity, residual solvents, particle size, and microbial quality. The material meets USP monograph specifications and is suitable for regulated pharmaceutical manufacturing and compounding.
The material is packaged in sealed, light-protective, tamper-evident containers. Available in laboratory, pilot, and commercial-scale quantities. Documentation includes Certificate of Analysis (CoA), Safety Data Sheet (SDS), and complete traceability.
Each batch is tested for identity (IR), assay on anhydrous basis, impurity profile, water content, and microbial limits. Technical support is available to assist with formulation development and regulatory compliance.
As with all CarboMer supplied hormone active ingredients, Estriol USP is supported by dependable global supply, stringent quality control, and expert technical guidance to ensure safe, effective, and consistent pharmaceutical product development.