Description

Erythromycin Ethyl Succinate USP

Erythromycin Ethyl Succinate USP is a high-purity macrolide antibiotic used in pharmaceutical formulations for the treatment of a wide range of bacterial infections, particularly those caused by gram-positive organisms and select gram-negative bacteria. Compliant with United States Pharmacopeia (USP) standards, it is an ester prodrug of Erythromycin designed to improve acid stability and oral bioavailability.
Erythromycin Ethyl Succinate is chemically designated as the Ethyl succinate ester of Erythromycin A. It appears as a white to off-white crystalline powder that is practically insoluble in water but dispersible in aqueous media and soluble in organic solvents, making it suitable for oral solid and reconstitutable suspension formulations.
In pharmaceutical applications, Erythromycin Ethyl Succinate USP is used in:
• Oral tablets and capsules for systemic antibacterial therapy
• Reconstitutable oral suspensions for pediatric use
• Treatment of respiratory tract, skin, and soft tissue infections
• Alternative therapy for patients with penicillin allergies
• Combination antimicrobial regimens
• Research involving macrolide antibiotics and protein synthesis inhibition
Erythromycin Ethyl Succinate USP functions by inhibiting bacterial protein synthesis through binding to the 50S ribosomal subunit, preventing translocation of peptides and thereby suppressing bacterial growth. The ethyl succinate ester improves stability in gastric conditions and is hydrolyzed in vivo to the active Erythromycin base.
CarboMer supplies Erythromycin Ethyl Succinate USP with control over assay, ester content, purity, residual solvents, particle size, and microbial quality. The material meets USP monograph specifications and is suitable for regulated pharmaceutical manufacturing.
The material is packaged in sealed, moisture-resistant, tamper-evident containers and protected from excessive heat and light. Available in laboratory, pilot, and commercial-scale quantities. Documentation includes Certificate of Analysis (CoA), Safety Data Sheet (SDS), and full traceability.
Each batch is tested for identity (IR, HPLC), assay on anhydrous basis, ester content, impurity profile, water content, and microbial limits. Technical support is available to assist with formulation development, suspension stability, and regulatory compliance.
As with all CarboMer supplied antibiotic ingredients, Erythromycin Ethyl Succinate USP is supported by dependable global supply, rigorous quality control, and expert technical guidance to ensure safe, effective, and consistent pharmaceutical product development.