Description

Digitonin USP

Digitonin USP is a high-purity steroidal saponin used in pharmaceutical research, biochemical applications, and analytical laboratories for its membrane-permeabilizing and cholesterol-binding properties. Compliant with United States Pharmacopeia (USP) standards, it is commonly utilized for selective solubilization of membrane proteins and controlled cell membrane permeabilization.
Digitonin is chemically designated as a steroidal glycoside derived from Digitalis species. It appears as a white to off-white amorphous powder that is sparingly soluble in water and freely soluble in alcohols. Its amphiphilic structure enables strong interaction with membrane cholesterol while preserving protein integrity.
In pharmaceutical, biochemical, and research applications, Digitonin USP is used in:
• Selective permeabilization of plasma membranes in cell biology studies
• Solubilization of membrane proteins for biochemical analysis
• Isolation and purification of cholesterol-rich membrane fractions
• Research involving lipid rafts and membrane dynamics
• Analytical methods for sterol quantification
• Development of controlled cell lysis and extraction protocols
Digitonin USP functions by forming complexes with Cholesterol in biological membranes, creating pores that allow controlled access to intracellular components. This selective action makes it particularly valuable in studies requiring intact organelles or partial membrane disruption.
CarboMer supplies Digitonin USP with control over assay, purity, residual solvents, particle size, and microbial quality. The material meets USP monograph specifications and is suitable for regulated pharmaceutical research and laboratory use.
The material is packaged in sealed, moisture-resistant, tamper-evident containers and protected from light. Available in laboratory and pilot-scale quantities. Documentation includes Certificate of Analysis (CoA), Safety Data Sheet (SDS), and complete traceability.
Each batch is tested for identity (IR), assay, impurity profile, loss on drying, and microbial limits. Technical support is available to assist with handling, solubilization techniques, and application-specific requirements.
As with all CarboMer supplied biochemical reagents and research-grade ingredients, Digitonin USP is supported by dependable global supply, rigorous quality control, and expert technical guidance to ensure consistent and reliable performance.