Description

Desipramine Hydrochloride USP

Desipramine Hydrochloride USP is a high-purity tricyclic antidepressant used in pharmaceutical formulations for the treatment of major depressive disorder, chronic pain syndromes, and certain anxiety-related conditions. Compliant with United States Pharmacopeia (USP) standards, it is the active metabolite of Imipramine and is valued for its relatively selective inhibition of norepinephrine reuptake.
Desipramine Hydrochloride is chemically designated as 10,11-Dihydro-5H-dibenz[b,f]azepine-5-propanamine hydrochloride. It appears as a white to off-white crystalline powder that is freely soluble in water and alcohol, enabling formulation into oral solid and liquid dosage forms.
In pharmaceutical applications, Desipramine Hydrochloride USP is used in:
• Oral tablets and capsules for treatment of depressive disorders
• Adjunct therapy for neuropathic and chronic pain management
• Treatment of attention-related and anxiety disorders in select cases
• Clinical research involving monoamine reuptake inhibition
• Pharmacological studies of tricyclic antidepressants
Desipramine Hydrochloride USP acts primarily by inhibiting the reuptake of Norepinephrine at synaptic junctions, increasing neurotransmitter availability in the central nervous system. Compared to other tricyclic antidepressants, it exhibits reduced sedative and anticholinergic effects, which can improve patient tolerability.
CarboMer supplies Desipramine Hydrochloride USP with control over assay, purity, residual solvents, particle size, and microbial quality. The material meets USP monograph specifications and is suitable for regulated pharmaceutical manufacturing and development.
The material is packaged in sealed, moisture-resistant, tamper-evident containers. Available in laboratory, pilot, and commercial-scale quantities. Documentation includes Certificate of Analysis (CoA), Safety Data Sheet (SDS), and complete traceability.
Each batch is tested for identity (IR, HPLC), assay on anhydrous basis, impurity profile, water content, and microbial limits. Technical support is available to assist with formulation development and regulatory compliance.
As with all CarboMer supplied central nervous system active ingredients, Desipramine Hydrochloride USP is supported by stringent quality control, and expert technical guidance to ensure safe, effective, and consistent pharmaceutical product development.