Description

Dermatan Sulfate

Dermatan Sulfate is a high-purity sulfated glycosaminoglycan used in pharmaceutical research, biomedical applications, and specialized therapeutic development. Structurally related to chondroitin sulfate, it is composed primarily of repeating disaccharide units of Iduronic acid and N-Acetylgalactosamine, conferring unique biological and anticoagulant properties distinct from Heparin.
Dermatan Sulfate appears as a white to off-white hygroscopic powder that is freely soluble in water, forming clear to slightly opalescent solutions. Its molecular structure enables strong interactions with proteins, enzymes, and growth factors, supporting diverse applications in coagulation research and tissue biology.
In pharmaceutical, biomedical, and research applications, Dermatan Sulfate is used in:
• Investigation of coagulation pathways and thrombin inhibition
• Research involving heparin cofactor II–mediated anticoagulant activity
• Drug delivery and biomaterial surface modification
• Tissue engineering and regenerative medicine studies
• Analysis of extracellular matrix structure and function
• Development of glycosaminoglycan-based therapeutic platforms
Dermatan Sulfate exhibits anticoagulant activity primarily through activation of heparin cofactor II, leading to inhibition of thrombin. Unlike Heparin, its activity is less dependent on antithrombin, giving it distinct biological behavior and research value.
CarboMer supplies Dermatan Sulfate with control over molecular weight distribution, sulfate content, purity, moisture content, and microbial quality. The material is suitable for regulated pharmaceutical research and biomedical development.
The material is packaged in sealed, moisture-resistant, tamper-evident containers. Available in laboratory and pilot-scale quantities. Documentation includes Certificate of Analysis (CoA), Safety Data Sheet (SDS), and complete traceability.
Each batch is tested for identity (IR), molecular weight profile, sulfate content, water content, and microbial limits. Technical support is available to assist with formulation development and application-specific requirements.
As with all CarboMer supplied glycosaminoglycans, Dermatan Sulfate is supported by rigorous quality control, and expert technical guidance to ensure consistent and reliable performance in advanced pharmaceutical and biomedical applications.