Description

Dantrolene Sodium

Dantrolene Sodium is a high-purity skeletal muscle relaxant used in pharmaceutical formulations for the treatment of malignant hyperthermia, chronic spasticity, and related neuromuscular conditions. It acts directly on skeletal muscle by interfering with excitation–contraction coupling, distinguishing it from centrally acting muscle relaxants.
Dantrolene Sodium is chemically designated as Sodium 1-[(5-(4-nitrophenyl)furfurylidene)amino]hydantoin. It appears as an orange to yellow crystalline powder that is slightly soluble in water and soluble in alkaline solutions. Due to its light sensitivity, it is handled and packaged under controlled conditions.
In pharmaceutical and clinical applications, Dantrolene Sodium is used in:
• Injectable formulations for emergency treatment of malignant hyperthermia
• Oral capsules for management of chronic spasticity associated with neurological disorders
• Perioperative and anesthetic care protocols
• Research involving calcium channel regulation and muscle physiology
• Controlled hospital and critical care settings
Dantrolene Sodium exerts its pharmacological effect by inhibiting calcium release from the sarcoplasmic reticulum in skeletal muscle fibers through antagonism of the ryanodine receptor (RyR1). This action reduces muscle contraction and prevents the hypermetabolic state characteristic of malignant hyperthermia.
CarboMer offers Dantrolene Sodium with control over assay, purity, residual solvents, particle size, and microbial quality. The material is suitable for regulated pharmaceutical manufacturing and emergency-use formulations.
The material is packaged in sealed, light-protective, tamper-evident containers. Available in laboratory, pilot, and commercial-scale quantities. Documentation includes Certificate of Analysis (CoA), Safety Data Sheet (SDS), and full traceability.
Each batch is tested for identity (IR, HPLC), assay, impurity profile, water content, and microbial limits. Technical support is available to assist with formulation considerations, stability, and compliance requirements.
As with all CarboMer supplied active pharmaceutical ingredients, Dantrolene Sodium is supported by dependable global supply, stringent quality control, and expert technical guidance to ensure safe, effective, and consistent pharmaceutical product development.