Description

Croscarmellose Sodium NF

Croscarmellose Sodium NF is a high-purity, crosslinked sodium carboxymethylcellulose used in pharmaceutical formulations as a super disintegrant. Compliant with National Formulary (NF) standards, it promotes rapid tablet and capsule disintegration by swelling and wicking mechanisms, ensuring fast and consistent drug release.
Croscarmellose Sodium appears as a white to off-white, odorless, free-flowing powder. It is insoluble in water but rapidly absorbs moisture and swells extensively upon contact with aqueous fluids. Its crosslinked structure provides high disintegration efficiency without forming gels, making it ideal for immediate-release dosage forms.
In pharmaceutical applications, Croscarmellose Sodium NF is used in:
• Immediate-release tablets and capsules as a super disintegrant
• Orally disintegrating tablets and fast-dissolve dosage forms
• Granulated and direct-compression tablet formulations
• Low-dose and high-potency drug products requiring uniform disintegration
• Combination disintegrant systems to optimize tablet performance
• Research and development of rapid-release oral dosage forms
Croscarmellose Sodium NF enhances drug bioavailability by enabling fast breakup of solid dosage forms upon ingestion. It functions through a combination of swelling, capillary action, and deformation recovery, providing reliable disintegration even at low use levels.
CarboMer offers Croscarmellose Sodium NF with control over degree of substitution, crosslink density, particle size distribution, moisture content, and microbial quality. The material meets NF monograph specifications and is suitable for regulated pharmaceutical manufacturing.
The material is packaged in sealed, moisture-resistant, tamper-evident containers. Available in laboratory, pilot, and commercial-scale quantities. Documentation includes Certificate of Analysis (CoA), Safety Data Sheet (SDS), and full traceability.
Each batch is tested for identity (IR), sodium content, loss on drying, pH, degree of substitution, and microbial limits. Technical support is available to assist with formulation optimization and performance evaluation.
As with all CarboMer supplied excipients, Croscarmellose Sodium NF is backed by dependable global supply, stringent quality control, and expert technical support to ensure safe, effective, and consistent pharmaceutical product development.