Description

Colistin Sulfate USP

Colistin Sulfate USP is a high-purity polypeptide antibiotic used in pharmaceutical formulations for the treatment of infections caused by Gram-Negative bacteria. Compliant with United States Pharmacopeia (USP) standards, it is commonly utilized in parenteral, inhalation, and topical dosage forms for management of multidrug-resistant infections.
Colistin Sulfate is a mixture of cyclic polypeptides, primarily Polymyxin E1 and Polymyxin E2, derived from Paenibacillus polymyxa. It appears as a white to off-white hygroscopic powder that is freely soluble in water and suitable for formulation into aqueous solutions and injectable preparations.
In pharmaceutical and research applications, Colistin Sulfate USP is used in:
• Injectable formulations for severe Gram-Negative infections
• Inhalation therapies for respiratory infections, including cystic fibrosis-related infections
• Topical formulations for localized infections
• Treatment of infections caused by multidrug-resistant organisms
• Research involving antimicrobial resistance mechanisms
• Development of last-line antibiotic therapies
Colistin Sulfate USP functions by interacting with the lipopolysaccharide layer of Gram-Negative bacterial membranes, disrupting membrane integrity and increasing permeability. This leads to leakage of intracellular contents and bacterial cell death.
CarboMer supplies Colistin Sulfate USP with defined assay, potency, impurity profile, and physicochemical characteristics suitable for regulated pharmaceutical manufacturing and formulation development.
The material meets USP monograph specifications and is appropriate for controlled pharmaceutical production environments.
The material is packaged in sealed, moisture-resistant, tamper-evident containers and protected from excessive light to preserve stability and handling quality. Available in laboratory, pilot, and commercial-scale quantities. Documentation includes Certificate of Analysis (CoA), Safety Data Sheet (SDS), and full traceability.
Each batch is tested for identity, potency, assay, impurity profile, water content, and microbial limits where applicable. Technical support is available to assist with formulation development, stability considerations, and regulatory alignment.
As with all CarboMer supplied antibacterial active ingredients, Colistin Sulfate USP is supported by dependable global supply, rigorous quality systems, and expert technical guidance to ensure consistent and reliable performance across pharmaceutical applications.