Description

Colistin Methanesulfate Sodium USP

Colistin Methanesulfate Sodium USP is a high-purity, semi-synthetic polypeptide antibiotic used in pharmaceutical formulations for the treatment of serious infections caused by multidrug-resistant gram-negative bacteria. Compliant with United States Pharmacopeia (USP) standards, it is a water-soluble prodrug of Colistin designed for parenteral and inhalation administration.
Colistin Methanesulfate Sodium is chemically designated as the Methanesulfonated sodium salt derivative of Colistin. It appears as a white to off-white hygroscopic powder that is freely soluble in water, enabling formulation into injectable solutions and nebulized preparations.
In pharmaceutical and clinical applications, Colistin Methanesulfate Sodium USP is used in:
• Injectable formulations for severe systemic infections
• Inhalation therapies for pulmonary infections, including cystic fibrosis–associated infections
• Treatment of infections caused by multidrug-resistant Pseudomonas aeruginosa, Acinetobacter baumannii, and Klebsiella species
• Hospital and critical care antimicrobial protocols
• Research involving polymyxin-class antibiotics
Colistin Methanesulfate Sodium USP is converted in vivo to the active antibiotic Colistin, which disrupts bacterial cell membrane integrity by interacting with lipopolysaccharides in the outer membrane of gram-negative bacteria. This leads to increased membrane permeability and rapid bacterial cell death.
CarboMer offers Colistin Methanesulfate Sodium USP with control over potency, assay, impurity profile, residual solvents, and microbial quality. The material meets USP monograph specifications and is suitable for regulated pharmaceutical manufacturing and hospital use.
The material is packaged in sealed, moisture-protective, tamper-evident containers. Available in laboratory, pilot, and commercial-scale quantities. Documentation includes Certificate of Analysis (CoA), Safety Data Sheet (SDS), and complete traceability.
Each batch is tested for identity (HPLC), potency, sulfate content, pH, water content, and microbial limits. Technical support is available to assist with formulation considerations, stability, and regulatory compliance.
As with all CarboMer supplied antibiotic active ingredients, Colistin Methanesulfate Sodium USP is supported by dependable global supply, stringent quality control, and expert technical assistance to ensure safe, effective, and consistent pharmaceutical product performance.