Description

Colchicine USP

Colchicine USP is a high-purity alkaloid used in pharmaceutical formulations for the treatment and prevention of gout flares, familial Mediterranean fever, and other inflammatory conditions. Compliant with United States Pharmacopeia (USP) standards, it exhibits potent anti-inflammatory activity by disrupting microtubule formation and inhibiting neutrophil migration and activation.
Colchicine is chemically designated as N-[(7S)-5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]acetamide. It appears as a yellow to pale yellow crystalline powder that is sparingly soluble in water and freely soluble in alcohol and chloroform, allowing formulation in solid oral dosage forms.
In pharmaceutical applications, Colchicine USP is used in:
• Oral tablets and capsules for acute gout flare management
• Long-term prophylaxis of gout and hyperuricemia-related inflammation
• Treatment of familial Mediterranean fever
• Anti-inflammatory research involving microtubule inhibition
• Controlled clinical and pharmacological studies
Colchicine USP acts by binding to tubulin and preventing its polymerization into microtubules. This mechanism disrupts mitosis and inhibits leukocyte migration, phagocytosis, and inflammatory mediator release, resulting in reduced inflammation without direct analgesic effects.
CarboMer offers Colchicine USP with control over assay, purity, residual solvents, particle size, and microbial quality. The material meets USP monograph specifications and is suitable for regulated pharmaceutical manufacturing and clinical use.
The material is packaged in sealed, light-protective, tamper-evident containers due to its photosensitivity. Available in laboratory, pilot, and commercial-scale quantities. Documentation includes Certificate of Analysis (CoA), Safety Data Sheet (SDS), and complete traceability.
Each batch is tested for identity (IR, HPLC), assay on anhydrous basis, impurity profile, water content, and microbial limits. Technical support is available to assist with formulation considerations and compliance requirements.
As with all CarboMer supplied active pharmaceutical ingredients, Colchicine USP is backed by dependable global supply, rigorous quality control, and expert technical support to ensure safe, effective, and consistent pharmaceutical product development.