Description

Clonidine Hydrochloride USP

Clonidine Hydrochloride USP is a high-purity centrally acting alpha-2 Adrenergic agonist used in pharmaceutical formulations for the management of hypertension, attention deficit hyperactivity disorder, neuropathic pain, and certain withdrawal syndromes. Compliant with United States Pharmacopeia (USP) standards, it is formulated for oral, transdermal, and injectable dosage forms requiring precise potency and consistent bioavailability.
Clonidine Hydrochloride is chemically designated as 2-[(2,6-Dichlorophenyl)amino]-2-imidazoline hydrochloride. It appears as a white to off-white crystalline powder that is freely soluble in water and alcohol, allowing flexible formulation across solid and liquid dosage forms.
In pharmaceutical applications, Clonidine Hydrochloride USP is used in:
• Oral tablets and solutions for hypertension management
• Extended-release formulations for pediatric and adult indications
• Transdermal therapeutic systems for sustained blood pressure control
• Adjunct therapy for pain management and opioid withdrawal
• Research and development involving central adrenergic modulation
Clonidine Hydrochloride USP acts by stimulating central alpha-2 Adrenergic receptors, reducing sympathetic outflow from the central nervous system. This leads to decreased peripheral vascular resistance, heart rate, and blood pressure. Its central mechanism also contributes to sedative and analgesic effects in select clinical applications.
CarboMer offers Clonidine Hydrochloride USP with control over assay, purity, residual solvents, particle size, and microbial quality. The material meets USP monograph specifications and is suitable for regulated pharmaceutical development and commercial manufacturing.
The material is packaged in sealed, moisture-resistant, tamper-evident containers. Available in laboratory, pilot, and commercial-scale quantities. Documentation includes Certificate of Analysis (CoA), Safety Data Sheet (SDS), and full traceability.
Each batch is tested for identity (IR, HPLC), assay on anhydrous basis, water content, impurity profile, and microbial limits. Technical support is available to assist with formulation considerations and regulatory compliance.
As with all CarboMer supplied active pharmaceutical ingredients, Clonidine Hydrochloride USP is backed by reliable global supply, stringent quality control, and expert technical support to ensure safe, effective, and consistent pharmaceutical product development.